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  • 1
    Online Resource
    Online Resource
    Rhinovirus species and clinical features in children hospitalised with pneumonia from Mozambique
    Wiley ; 2016
    In:  Tropical Medicine & International Health Vol. 21, No. 9 ( 2016-09), p. 1171-1180
    Details
    In: Tropical Medicine & International Health, Wiley, Vol. 21, No. 9 ( 2016-09), p. 1171-1180
    Abstract: Describir la prevalencia de las especies de rinovirus ( RV ) humano en niños hospitalizados con neumonía en Manhiça, Mozambique; y las asociaciones entre las especies RV y características demográficas, clínicas, y de laboratorio. Métodos Se recolectaron aspirados nasofaríngeos de niños con 0‐10 años de edad ( n  = 277) que se presentaron en el Hospital Distrital de Manhiça con neumonía clínica. Se tomaron muestras de sangre para realizar pruebas para VIH y malaria, hemocultivos y hemogramas completos, y se tomó una placa de tórax. Se investigó la presencia de un panel de virus respiratorios comunes mediante dos ensayos independientes de multiplex RT ‐ PCR con cebadores específicos para cada virus y tipo de virus. Se identificaron las especies de RV y sus genotipos mediante una PCR semi‐anidada, secuenciación y análisis de árbol filogenético. Resultados Se identificó al menos un virus respiratorio en 206 (74.4%) niños hospitalizados con neumonía clínica. El RV fue el virus más comúnmente identificado, tanto en niños infectados con VIH (17/38, 44.7%) como en aquellos sin infectar (74/237, 31.2%; P  = 0.100). La especie de RV más común era el RV ‐A (47/275, 17.0%), seguida por RV ‐C (35/275, 12.6%) y RV ‐B (8/275, 2.9%). Las presentaciones clínicas de las diferentes especies de RV eran similares y se solapaban, sin que ninguna especie en particular estuviese asociada con características clínicas específicas. Conclusiones RV ‐A y RV ‐C fueron los virus respiratorios más comúnmente identificados en niños hospitalizados con neumonía clínica en Manhiça. Las presentaciones clínicas de RV ‐A y RV ‐C eran similares y se solapaba.
    Type of Medium: Online Resource
    ISSN: 1360-2276 , 1365-3156
    URL: Issue
    URL: Article
    DOI: 10.1111/tmi.2016.21.issue-9
    DOI: 10.1111/tmi.12743
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2018112-7
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  • 2
    Online Resource
    Online Resource
    Western environment/lifestyle is associated with increased genome methylation and decreased gene expression in C hinese immigrants living in A ustralia
    Wiley ; 2016
    In:  Environmental and Molecular Mutagenesis Vol. 57, No. 1 ( 2016-01), p. 65-73
    Details
    In: Environmental and Molecular Mutagenesis, Wiley, Vol. 57, No. 1 ( 2016-01), p. 65-73
    Abstract: Introduction: Several human diseases and conditions are disproportionally distributed in the world with a significant “Western‐developed” vs. “Eastern‐developing” gradient. Methods: We compared genome‐wide DNA methylation of peripheral blood mononuclear cells in 25 newly arrived Chinese immigrants living in a Western environment for less than 6 months (“Newly arrived”) with 23 Chinese immigrants living in the Western environment for more than two years (“Long‐term”) with a mean of 8.7 years, using the Infinium HumanMethylation450 BeadChip. In a sub‐group of both subject groups ( n  = 12 each) we also investigated genome‐wide gene expression using a Human HT‐12 v4 expression beadChip. Results: There were 62.5% probes among the total number of 382,250 valid CpG sites with greater mean Beta (β) in “Long‐term” than in “Newly arrived”. In the regions of CpG islands and gene promoters, compared with the CpG sites in all other regions, lower percentages of CpG sites with mean methylation levels in “Long‐term” greater than “Newly arrived” were observed, but still 〉 50%. The increase of methylation was associated with a general decrease of gene expression in Chinese immigrants living in the Western environment for a longer period of time. After adjusting for age, gender and other confounding factors the findings remained. Conclusion: Chinese immigrants living in Australia for a longer period of time have increased overall genome methylation and decreased overall gene expression compared with newly arrived immigrants. Environ. Mol. Mutagen. 57:65–73, 2016. © 2015 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0893-6692 , 1098-2280
    URL: Issue
    URL: Article
    DOI: 10.1002/em.v57.1
    DOI: 10.1002/em.21989
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 1497682-1
    SSG: 12
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  • 3
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    Online Resource
    Rhinovirus C is associated with wheezing and rhinovirus A is associated with pneumonia in hospitalized children in Morocco
    Wiley ; 2017
    In:  Journal of Medical Virology Vol. 89, No. 4 ( 2017-04), p. 582-588
    Details
    In: Journal of Medical Virology, Wiley, Vol. 89, No. 4 ( 2017-04), p. 582-588
    Abstract: Human rhinovirus (RV) is commonly associated with severe acute lower respiratory infections (ALRI) in children. We aimed to describe the distribution of RV species and associations between RV species and clinical features in children hospitalized with clinically severe pneumonia (CSP) in Morocco. Nasopharyngeal aspirates (NPAs) were collected from 700 children, 2–59 months of age, admitted with CSP to the Hôpital d'Enfants de Rabat in Morocco. At least one respiratory virus was identified in 92% of children, of which RV was the most common (53%). PCR assays, sequencing, and phylogenetic tree analyses were carried out on 183 RV‐positive NPAs to determine RV species and genotypes. Of 157 successfully genotyped NPAs, 60 (38.2%) were RV‐A, 8 (5.1%) were RV‐B, and 89 (56.7%) were RV‐C. Wheezing and cyanosis were more common in RV‐C‐positive than RV‐A‐positive children (80.9% vs. 56.7%; P  = 0.001 for wheezing and 10.1% vs. 0%; P  = 0.011 for cyanosis). Physician's discharge diagnosis of pneumonia was more frequent among RV‐A‐positive (40.0%) than RV‐C‐positive children (20.2%; P  = 0.009). RV‐A and RV‐C showed distinct seasonal patterns. Our findings suggest that RV‐C is associated with wheezing illness while RV‐A is associated with pneumonia. J. Med. Virol. 89:582–588, 2017 . © 2016 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v89.4
    DOI: 10.1002/jmv.24684
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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