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  • 1
    Online Resource
    Online Resource
    Molecular Diversity of K + Channels
    Wiley ; 1999
    In:  Annals of the New York Academy of Sciences Vol. 868, No. 1 ( 1999-04), p. 233-255
    Details
    In: Annals of the New York Academy of Sciences, Wiley, Vol. 868, No. 1 ( 1999-04), p. 233-255
    Abstract: ABSTRACT: K + channel principal subunits are by far the largest and most diverse of the ion channels. This diversity originates partly from the large number of genes coding for K + channel principal subunits, but also from other processes such as alternative splicing, generating multiple mRNA transcripts from a single gene, heteromeric assembly of different principal subunits, as well as possible RNA editing and posttranslational modifications. In this chapter, we attempt to give an overview (mostly in tabular format) of the different genes coding for K + channel principal and accessory subunits and their genealogical relationships. We discuss the possible correlation of different principal subunits with native K + channels, the biophysical and pharmacological properties of channels formed when principal subunits are expressed in heterologous expression systems, and their patterns of tissue expression. In addition, we devote a section to describing how diversity of K + channels can be conferred by heteromultimer formation, accessory subunits, alternative splicing, RNA editing and posttranslational modifications. We trust that this collection of facts will be of use to those attempting to compare the properties of new subunits to the properties of others already known or to those interested in a comparison between native channels and cloned candidates.
    Type of Medium: Online Resource
    ISSN: 0077-8923 , 1749-6632
    URL: Issue
    URL: Article
    DOI: 10.1111/nyas.1999.868.issue-1
    DOI: 10.1111/j.1749-6632.1999.tb11293.x
    RVK:
    TD 7650
    Language: English
    Publisher: Wiley
    Publication Date: 1999
    detail.hit.zdb_id: 2834079-6
    detail.hit.zdb_id: 211003-9
    detail.hit.zdb_id: 2071584-5
    SSG: 11
    Location Call Number Limitation Availability
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  • 2
    Online Resource
    Online Resource
    Contributions of Kv3 Channels to Neuronal Excitability
    Wiley ; 1999
    In:  Annals of the New York Academy of Sciences Vol. 868, No. 1 ( 1999-04), p. 304-343
    Details
    In: Annals of the New York Academy of Sciences, Wiley, Vol. 868, No. 1 ( 1999-04), p. 304-343
    Abstract: ABSTRACT: Four mammalian Kv3 genes have been identified, each of which generates, by alternative splicing, multiple protein products differing in their C‐terminal sequence. Products of the Kv3.1 and Kv3.2 genes express similar delayed‐rectifier type currents in heterologous expression systems, while Kv3.3 and Kv3.4 proteins express A‐type currents. All Kv3 currents activate relatively fast at voltages more positive than −10 mV, and deactivate very fast. The distribution of Kv3 mRNAs in the rodent CNS was studied by in situ hybridization, and the localization of Kv3.1 and Kv3.2 proteins has been studied by immunohistochemistry. Most Kv3.2 mRNAs (∼90%) are present in thalamic‐relay neurons throughout the dorsal thalamus. The protein is expressed mainly in the axons and terminals of these neurons. Kv3.2 channels are thought to be important for thalamocortical signal transmission. Kv3.1 and Kv3.2 proteins are coexpressed in some neuronal populations such as in fast‐spiking interneurons of the cortex and hippocampus, and neurons in the globus pallidus. Coprecipitation studies suggest that in these cells the two types of protein form heteromeric channels. Kv3 proteins appear to mediate, in native neurons, similar currents to those seen in heterologous expression systems. The activation voltage and fast deactivation rates are believed to allow these channels to help repolarize action potentials fast without affecting the threshold for action potential generation. The fast deactivating current generates a quickly recovering afterhyperpolarization, thus maximizing the rate of recovery of Na + channel inactivation without contributing to an increase in the duration of the refractory period. These properties are believed to contribute to the ability of neurons to fire at high frequencies and to help regulate the fidelity of synaptic transmission. Experimental evidence has now become available showing that Kv3.1‐Kv3.2 channels play critical roles in the generation of fast‐spiking properties in cortical GABAergic interneurons.
    Type of Medium: Online Resource
    ISSN: 0077-8923 , 1749-6632
    URL: Issue
    URL: Article
    DOI: 10.1111/nyas.1999.868.issue-1
    DOI: 10.1111/j.1749-6632.1999.tb11295.x
    RVK:
    TD 7650
    Language: English
    Publisher: Wiley
    Publication Date: 1999
    detail.hit.zdb_id: 2834079-6
    detail.hit.zdb_id: 211003-9
    detail.hit.zdb_id: 2071584-5
    SSG: 11
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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