In:
Clinical Transplantation, Wiley, Vol. 28, No. 6 ( 2014-06), p. 749-754
Abstract:
Kidneys procured by donation after cardiac death ( DCD ) may increase the donor pool but are associated with high incidence of delayed graft function ( DGF ). Urinary liver‐type fatty acid‐binding protein ( L ‐ FABP ) level is an early biomarker of renal injury after kidney transplantation ( KT x); however, its utility is limited in DGF cases owing to urine sample unavailability. We examined whether serum L ‐ FABP level predicts functional recovery of transplanted DCD kidneys. Consecutive patients undergoing KT x from living related donors ( LD ), brain‐dead donors ( BD ), or DCD were retrospectively enrolled. Serum L ‐ FABP levels were measured from samples collected before and after KT x. Serum L ‐ FABP decreased rapidly in patients with immediate function, slowly in DGF patients, and somewhat increased in DGF patients requiring hemodialysis ( HD ) for 〉 1 wk. Receiver‐operating characteristic curve analysis demonstrated that DGF was predicted with 84% sensitivity ( SE ) and 86% specificity ( SP ) at cutoff of 9.0 ng/mL on post‐operative day ( POD ) 1 and 68% SE and 90% SP at 6.0 on POD 2. DGF 〉 7 d was predicted with 83% SE and 78% SP at 11.0 on POD 1 and 67% SE and 78% SP at 6.5 on POD 2. Serum L ‐ FABP levels may predict graft recovery and need for HD after DCD KT x.
Type of Medium:
Online Resource
ISSN:
0902-0063
,
1399-0012
DOI:
10.1111/ctr.2014.28.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2739458-X
detail.hit.zdb_id:
2004801-4
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