In:
Oncology, S. Karger AG, Vol. 90, No. 4 ( 2016), p. 186-192
Abstract:
〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 We assessed the clinical applicability of the F-NLR score, which is based on fibrinogen (F) and the neutrophil-lymphocyte ratio (NLR), and the Glasgow Prognostic Score (GPS) to predict the therapeutic effects of chemotherapy or chemoradiotherapy on advanced gastric cancer and the prognoses of patients. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Sixty-eight patients with advanced gastric cancer treated with first-line chemotherapy or chemoradiotherapy were classified into two groups based on tumor response. Furthermore, we categorized patients according to cutoff F-NLR scores of 2 [hyperfibrinogenemia ( 〉 400 mg/dl) and high NLR ( 〉 3.0)], 1 [one of these hematological abnormalities] , and 0 [neither hyperfibrinogenemia nor high NLR]. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A total of 27 patients had progressive disease (PD) and 41 did not. The F-NLR scores were significantly higher in the PD than in the non-PD group (p = 0.003). Survival was significantly shorter for patients with high F-NLR scores and GPS (p = 0.0071 and p = 0.0065, respectively). Multivariate analysis selected the F-NLR score as an independent prognostic factor (p = 0.017). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 A novel grading system based on F-NLR scores, as well as the GPS, appears to have value as a clinical predictor of the therapeutic response of advanced gastric cancer to chemotherapy or chemoradiotherapy and the prognoses of patients.
Type of Medium:
Online Resource
ISSN:
0030-2414
,
1423-0232
Language:
English
Publisher:
S. Karger AG
Publication Date:
2016
detail.hit.zdb_id:
1483096-6
detail.hit.zdb_id:
250101-6
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