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  • 1
    Online Resource
    Online Resource
    Nanoemulsion for delivery of anticancer drugs
    TMR Publishing Group ; 2022
    In:  Cancer Advances Vol. 5, No. 0 ( 2022), p. e22016-
    Details
    In: Cancer Advances, TMR Publishing Group, Vol. 5, No. 0 ( 2022), p. e22016-
    Type of Medium: Online Resource
    ISSN: 2815-7125
    URL: Article
    DOI: 10.53388/2022522016
    Language: English
    Publisher: TMR Publishing Group
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    Therapeutic Application of Pineapple: A Review
    Bentham Science Publishers Ltd. ; 2023
    In:  Recent Advances in Food, Nutrition & Agriculture Vol. 14, No. 2 ( 2023-08), p. 107-125
    Details
    In: Recent Advances in Food, Nutrition & Agriculture, Bentham Science Publishers Ltd., Vol. 14, No. 2 ( 2023-08), p. 107-125
    Abstract: Ananas comosus L. (family Bromeliaceae) is a plant innate to South America and has been cultivated in various world regions. The plant parts have traditionally been used to treat various ailments, like cancer, diabetes mellitus, bacterial infection, Covid-19 infection, inflammation, arthritis, asthma, malaria, cardiovascular disease, and burn, as debridement agents. The pineapple contains nutrients, including vitamin C, iron, potassium, and protein. It also contains flavonoids, carotenoids, tannins, polyphenols, and alkaloids. Methods: An extensive literature search was conducted on Ananas comosus using three scientific databases: PubMed, Scopus, and Web of Science. The keywords in this paper were combined to form a search strategy. Ananas comosus and pineapple were the main criteria for judging abstracts, titles, and keywords. In the full text of the paper, the secondary judgment criteria included mentioning "therapeutic potential" or "pharmacological activities”. Among the 250 references in the compiled bibliography, there were original articles, books, and web addresses dating back to 2001 to 2023. A review of articles was conducted after abstracts and titles were screened, and 61 duplicate articles were deleted. In this paper, information is provided on the therapeutic potential and pharmacological actions of Ananas comosus and its bioactive compounds. Results: In this review, the therapeutic potential of A. comosus has been detailed. The current review intends to provide an updated comprehensive overview of the versatile plant's use and its clinical trials. Conclusion: The plant has gained enormous attention and increasing consideration for treating various diseases. The therapeutic potential of pineapple, its compound, extracts, and their mode of action are discussed briefly. Also, clinical trials are emphasized, which are in great demand and need further in-depth investigation in the future.
    Type of Medium: Online Resource
    ISSN: 2772-574X
    URL: Article
    DOI: 10.2174/2772574X14666230522114039
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    An update review on drug repurposing for COVID-19
    TMR Publishing Group ; 2022
    In:  TMR Pharmacology Research Vol. 2, No. 3 ( 2022), p. 12-
    Details
    In: TMR Pharmacology Research, TMR Publishing Group, Vol. 2, No. 3 ( 2022), p. 12-
    Type of Medium: Online Resource
    ISSN: 2744-4341
    URL: Article
    DOI: 10.53388/PR202202012
    Language: English
    Publisher: TMR Publishing Group
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    Nanostructured materials used in drug delivery
    Elsevier BV ; 2022
    In:  Materials Today: Proceedings Vol. 69 ( 2022), p. 174-180
    Details
    In: Materials Today: Proceedings, Elsevier BV, Vol. 69 ( 2022), p. 174-180
    Type of Medium: Online Resource
    ISSN: 2214-7853
    URL: Article
    DOI: 10.1016/j.matpr.2022.08.306
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2797693-2
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  • 5
    Online Resource
    Online Resource
    Traditional Use, Phytochemistry and Pharmacology of Ananas comosus (L.) Merr.(Family Bromeliaceae): An Update
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Nutrition & Food Science Vol. 19, No. 4 ( 2023-05), p. 428-441
    Details
    In: Current Nutrition & Food Science, Bentham Science Publishers Ltd., Vol. 19, No. 4 ( 2023-05), p. 428-441
    Abstract: Ananas comosus belongs to the family Bromeliaceae and commonly known as pineapple, anannas and anannaasa. Objective: The present review gives detailed information about synonyms, geographical distribution, taxonomical classification, cultivation, pharmacognostical and phytochemical profile as well as about therapeutic potential of Ananas comosus. Methods: For the preparation of manuscript, all the information was collected from scientific engines and databases (Web of Science, Scifinder, Google Scholar, Scopus, PubMed, Wiley Online Library, Taylor & Francis online) using different keywords. Result: Recent studies of A.comosus are based on traditional use, phytochemistry and pharmacology. The nutritional properties of the fruit are well known. The fruit contains various biological active phytoconstituents such as polyphenol compounds, volatile compound and carotenoids etc. which are therapeutically active. A.comosus is used for digestive issues, inflammation, in sea sickness and in a sore throat. Different studies on A.comosus have been conducted due to ethanopharmacological profile. It possesses antimalarial, antidiabetic, abortifacient, anticancer, antioxidant and antidiarrhoeal activity etc. Finally Industrial applications and ongoing clinical trials on pineapple are also summarized. Conclusion: This review would assist researchers in formulating a therapeutically active herbal remedy.
    Type of Medium: Online Resource
    ISSN: 1573-4013
    URL: Article
    DOI: 10.2174/1573401318666220509140201
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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  • 6
    Online Resource
    Online Resource
    Role of Pineapple and its Bioactive Compound Bromelain in COVID 19
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Nutrition & Food Science Vol. 19 ( 2023-04-18)
    Details
    In: Current Nutrition & Food Science, Bentham Science Publishers Ltd., Vol. 19 ( 2023-04-18)
    Abstract: Ananas comosus (L.) Merr., which is commonly known as pineapple, is a well-studied plant for its medicinal properties. In terms of commercial importance, it ranks third among tropical fruits. It has been used for its antidiabetic, antimalarial, anticancer, abortifacient, antioxidant, and antidiarrhoeal activities. This review was planned to study the antiviral effects of pineapple and its bioactive compounds against SARS-CoV-2. Methods:: Research methods comprise significant studies on the treatment of COVID-19 utilizing pineapple and its bioactive compounds. To carry out the e-literature review, articles were downloaded from online search engines, including Elsevier, PubMed, and Google Scholar, using pineapple, bioactive compounds, bromelain, clinical trial, and COVID-19. Results:: The literature showed that pineapple and its bioactive compounds showed antiviral effects in COVID-19 patients by inhibiting the proinflammatory cytokines and affecting various signaling molecules, including NF-kβ, proinflammatory cytokines, and cyclooxygenase-2. They modulate apoptotic protein levels and also cause a reduction of ACE-2 and TMPRSS2 expression. Conclusion:: For the development of phytomedicine that adheres to all safety regulations, pineapple, and its bioactive compounds can serve as lead molecules for clinical studies in SARS-CoV-2 infection treatment and therapy.
    Type of Medium: Online Resource
    ISSN: 1573-4013
    URL: Article
    DOI: 10.2174/1573401319666230418104554
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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  • 7
    Online Resource
    Online Resource
    Role of traditional herbal medicine in treatment of malaria
    TMR Publishing Group ; 2022
    In:  TMR Modern Herbal Medicine Vol. 5, No. 4 ( 2022), p. 20-
    Details
    In: TMR Modern Herbal Medicine, TMR Publishing Group, Vol. 5, No. 4 ( 2022), p. 20-
    Type of Medium: Online Resource
    ISSN: 2537-9798
    URL: Article
    DOI: 10.53388/MHM2022B0816001
    Language: English
    Publisher: TMR Publishing Group
    Publication Date: 2022
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  • 8
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    Online Resource
    Drug delivery and testing via 3D printing
    Elsevier BV ; 2023
    In:  Bioprinting Vol. 36 ( 2023-12), p. e00298-
    Details
    In: Bioprinting, Elsevier BV, Vol. 36 ( 2023-12), p. e00298-
    Type of Medium: Online Resource
    ISSN: 2405-8866
    URL: Article
    DOI: 10.1016/j.bprint.2023.e00298
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2879065-0
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  • 9
    Online Resource
    Online Resource
    Bromelain: a review of its mechanisms, pharmacological effects and potential applications
    Royal Society of Chemistry (RSC) ; 2023
    In:  Food & Function Vol. 14, No. 18 ( 2023), p. 8101-8128
    Details
    In: Food & Function, Royal Society of Chemistry (RSC), Vol. 14, No. 18 ( 2023), p. 8101-8128
    Abstract: The utilization of plant-derived supplements for disease prevention and treatment has long been recognized because of their remarkable potential. Ananas comosus , commonly known as pineapple, produces a group of enzymes called bromelain, which contains sulfhydryl moieties. Recent studies have shown that bromelain exhibits a wide range of activities, including anti-inflammatory, anti-diabetic, anti-cancer, and anti-rheumatic properties. These properties make bromelain a promising drug candidate for the treatment of various diseases. The anti-inflammatory activity of bromelain has been shown to be useful in treating inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and asthma, whereas the anti-cancer activity of bromelain is via induction of apoptosis, inhibition of angiogenesis, and enhancement of the body's immune response. The anti-diabetic property of bromelain is owing to the improvement in glucose metabolism and reduction in insulin resistance. The therapeutic potential of bromelain has been investigated in numerous preclinical and clinical studies and a number of patents have been granted to date. Various formulations and delivery systems are being developed in order to improve the efficacy and safety of this molecule, including the microencapsulated form to treat oral inflammatory conditions and liposomal formulations to treat cancer. The development of novel drug delivery systems and formulations has further ameliorated the therapeutic potential of bromelain by improving its bioavailability and stability, while reducing the side effects. This review intends to discuss various properties and therapeutic applications of bromelain, along with its possible mechanism of action in treating various diseases. Recent patents and clinical trials concerning bromelain have also been covered.
    Type of Medium: Online Resource
    ISSN: 2042-6496 , 2042-650X
    URL: Article
    DOI: 10.1039/D3FO01060K
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2578152-2
    SSG: 21
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  • 10
    Online Resource
    Online Resource
    An updated review of pineapple and its bioactive compounds in breast cancer
    TMR Publishing Group ; 2023
    In:  Cancer Advances Vol. 6, No. 0 ( 2023), p. e23005-
    Details
    In: Cancer Advances, TMR Publishing Group, Vol. 6, No. 0 ( 2023), p. e23005-
    Type of Medium: Online Resource
    ISSN: 2815-7125
    URL: Article
    DOI: 10.53388/2023623005
    Language: English
    Publisher: TMR Publishing Group
    Publication Date: 2023
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