In:
American Journal of Reproductive Immunology, Wiley, Vol. 74, No. 3 ( 2015-09), p. 216-227
Abstract:
Regulatory T cells (Treg) are a T‐cell subpopulation with suppressive capacities, specifically attracted by CCL 22. We aimed to investigate whether CCL 22 is expressed in human placentas and whether its presence, together with Treg infiltration, is associated with miscarriage conditions. Method of study Paraffin samples were stained for CCL 22 and for the Treg‐specific transcription factor FoxP3. Expression levels were evaluated in a semi‐quantitative manner. Double immunofluorescence was used for the identification of CCL 22‐producing cells. Results In all placentas, trophoblasts expressed CCL 22. Interestingly, expression in the decidua was only observed in miscarriage conditions. Maternal stromal cells expressed CCL 22. Correlation with a higher presence of Treg in the decidua of abortive tissues was observed. Conclusion Our results demonstrate that CCL 22 is expressed in human placenta. Decidual expression was only observed in miscarriage conditions and correlates with Treg infiltration. Thus, CCL 22 plays a role in human pregnancy and may occur as a negative feedback response to pro‐inflammatory events during miscarriage conditions.
Type of Medium:
Online Resource
ISSN:
1046-7408
,
1600-0897
DOI:
10.1111/aji.2015.74.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2024667-5
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