In:
FEBS Letters, Wiley, Vol. 339, No. 1-2 ( 1994-02-14), p. 76-78
Abstract:
In order to investigate the role of type II phospholipase A 2 (PLA 2 ) in the inflammatory process, the effect of a monoclonal antibody specific to type II PLA 2 on carrageenan‐induced pleurisy was studied in rats. Intravenous injection of the antibody (MB5.2), which inhibits the catalytic activity of type II PLA 2 , significantly reduced both the pleural exudate volume and the intrapleural leukoeyte count, while a control antibody did not have any appreciable effect. MB5.2 caused no change in the level of type II PLA 2 in the pleural fluid. These results suggest that type II PLA 2 generated at inflamed sites, at least in part, have a crucial role in the pathogenesis of acute inflammation.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(94)80388-9
Language:
English
Publisher:
Wiley
Publication Date:
1994
detail.hit.zdb_id:
1460391-3
SSG:
12
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