In:
Journal of Hepato-Biliary-Pancreatic Sciences, Wiley, Vol. 30, No. 5 ( 2023-05), p. 664-677
Abstract:
We attempted to determine the indications and limitations of steroid therapy as the first‐line therapy in patients with autoimmune pancreatitis (AIP) with cyst formation (ACF). Methods This Japanese multicenter survey was conducted to examine the merits/demerits of steroid treatment as the initial therapy for ACF. Results Data of a total of 115 patients with ACF were analyzed. Complete remission was achieved in 86% (86/100) of patients who had received steroid treatment, but only 33.3% (5/15) of patients who had not received steroids. Relapse after the remission (n = 86) occurred in 7.6% (6/86) of patients who had received steroid therapy, but 40% (2/5) of patients who had not received steroid therapy. Multivariate analysis identified adoption of the wait and watch approach without steroid treatment (odds ratio = 0.126, P 〈 .001) as a significant and independent negative predictor of remission of ACF. As for predictors of relapse, the presence of varix (odds ratio = 5.83, P = .036) was identified as an independent risk factor. Conclusion Steroid therapy plays an important role as first‐line therapy in AIP patients with pancreatic cyst formation, however, varix formation, besides the diameter of the cyst(s), is a risk factor for refractoriness to steroid therapy.
Type of Medium:
Online Resource
ISSN:
1868-6974
,
1868-6982
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2536390-6
Permalink