In:
European Journal of Immunology, Wiley, Vol. 26, No. 2 ( 1996-02), p. 505-507
Abstract:
The fetal syncytiotrophoblast cells in close contact with maternal blood circulation apparently lack surface expression of HLA molecules, including the HLA light chain β2‐microglobulin. This is thought to contribute significantly to a successful pregnancy. We find that syncytiotrophoblasts do express β2‐microglobulin. β2‐microglobulin is primarily localized intracellularly in apical granules, and co‐localize with human IgG. The origin and function of syncytiotrophoblast β2‐microglobulin is unknown, but its localization in the syncytiotrophoblasts may implicate β2‐microglobulin in the transplacental transport of IgG in conjunction with a recently identified class I HLA‐like receptor for IgG/Fc. Alternatively, β2‐microglobulin may associate with a hitherto unidentified class I HLA molecule.
Type of Medium:
Online Resource
ISSN:
0014-2980
,
1521-4141
DOI:
10.1002/eji.1830260234
Language:
English
Publisher:
Wiley
Publication Date:
1996
detail.hit.zdb_id:
1491907-2
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