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  • 1
    Online Resource
    Online Resource
    Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease
    Springer Science and Business Media LLC ; 2021
    In:  Scientific Reports Vol. 11, No. 1 ( 2021-09-16)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-09-16)
    Abstract: Oxidative stress is assumed to be the underlying feature of non-alcoholic fatty liver disease (NAFLD). To our knowledge, the mutual involvement of redox status homeostasis parameters [i.e., advanced oxidation protein products (AOPP), pro-oxidant-antioxidant balance (PAB), total oxidant status (TOS), total antioxidant status (TAS) and oxidative-stress index (OSI)] and cardiometabolic biomarkers in subjects with NAFLD has not been examined yet. Accordingly, we aimed to investigate t his potential relationship. A total of 122 subjects with NAFLD were compared with 56 participants without NAFLD. The diagnosis of NAFLD was confirmed by abdominal ultrasound. Anthropometric and biochemical parameters were measured. OSI, Castelli’s Risk Index I (CRI-I) and Castelli’s Risk Index II (CRI-II) were calculated. Univariate and multivariate binary logistic regression analysis were used to test the predictions of oxidative stress and cardiometabolic markers, respectively for NAFLD. Principal component analysis (PCA) was applied to explore its mutual effect on NAFLD status. Significant positive associations of CRI-I, CRI-II, high sensitivity C-reactive protein (hsCRP) and AOPP with NAFLD were found. PCA analysis extracted 3 significant factors: Oxidative stress-cardiometabolic related factor (i.e., triglycerides, AOPP, HDL-c and HbA1c)-explained 36% of variance; Pro-oxidants related factor (i.e., TOS and PAB)-explained 17% of variance; and Antioxidants related factor (i.e., TAS)-explained 15% of variance of the tested parameters. Moreover, binary logistic regression analysis revealed significant predictive ability of Oxidative stress-cardiometabolic related factor ( p   〈  0.001) and Pro-oxidants related factor ( p   〈  0.05) for NAFLD status. In addition to oxidative stress (i.e., determined by higher AOPP levels), dyslipidemia (i.e., determined by higher lipid indexes: CRI-I and CRI-II) and inflammation (determined by higher hsCRP) are independently related to NAFLD status. The mutual involvement of pro-oxidants (i.e., TOS and PAB), or the joint involvement of pro-oxidants (i.e., AOPP) and cardiometabolic parameters (i.e., HbA1c, triglycerides and HDL-c) can differentiate subjects with NAFLD from those individuals without this metabolic disorder. New studies are needed to validate our results in order to find the best therapeutic approach for NAFLD.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-021-97686-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2615211-3
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  • 2
    Online Resource
    Online Resource
    The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women
    Springer Science and Business Media LLC ; 2018
    In:  Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Vol. 23, No. 1 ( 2018-2), p. 133-141
    Details
    In: Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2018-2), p. 133-141
    Type of Medium: Online Resource
    ISSN: 1124-4909 , 1590-1262
    URL: Article
    DOI: 10.1007/s40519-016-0325-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2061177-8
    SSG: 5,2
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  • 3
    Online Resource
    Online Resource
    Relationship between Cardiovascular Risk Score and Traditional and Nontraditional Cardiometabolic Parameters in Obese Adolescent Girls
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2016
    In:  Journal of Medical Biochemistry Vol. 35, No. 3 ( 2016-09-1), p. 282-292
    Details
    In: Journal of Medical Biochemistry, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 35, No. 3 ( 2016-09-1), p. 282-292
    Abstract: Background: Since the cardiovascular (CV) risk score in the young population, children and adolescents, is underestimated, especially in developing countries such as Montenegro, where a strong interaction exists between the genetically conditioned CV risk and environmental factors, the purpose of this study was to estimate CV risk in apparently healthy adolescent girls. Moreover, we aimed to test some new, emerging CV risk factors and their interaction with the traditional ones, such as obesity. Precisely, we aimed to assess the impact of low bilirubin levels, as a routine biochemical parameter, as an additional risk factor for atherosclerotic disease in the adult phase. Methods: Forty-five obese adolescent girls (mean age 17.8±1.22 years) and forty-five age-and sex-matched normal weight controls, all nonsmokers, were included. Anthropometric and biochemical parameters were measured. Cardiovascular Risk Score (CVRS) was calculated by adding the points for each risk factor (e.g. sex, HDL-c, non-HDLc, blood pressure and fasting glycemia). Results: A significant positive relationship between CVRS and ALT, hsCRP and TG/HDL-c, but an opposite relationship between CVRS and total bilirubin were found (P 〈 0.001). Multiple linear regression analysis showed that higher waist circumference (WC) and LDL-c, but lower HDL-c were independent predictors of lower bilirubin values (adjusted R 2 =0.603, P 〈 0.001). Conclusions: Obese adolescent girls are at an increased risk of cardiovascular disease late in life. In addition to the traditional risk factors, total bilirubin may have the potential to discriminate between low and higher risk for cardiovascular disturbances in healthy adolescent girls.
    Type of Medium: Online Resource
    ISSN: 1452-8266
    URL: Article
    DOI: 10.1515/jomb-2016-0005
    Language: Unknown
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2016
    detail.hit.zdb_id: 2405112-3
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  • 4
    Online Resource
    Online Resource
    Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women
    Termedia Sp. z.o.o. ; 2017
    In:  Archives of Medical Science Vol. 5 ( 2017), p. 1188-1196
    Details
    In: Archives of Medical Science, Termedia Sp. z.o.o., Vol. 5 ( 2017), p. 1188-1196
    Type of Medium: Online Resource
    ISSN: 1734-1922
    URL: Article
    DOI: 10.5114/aoms.2017.68972
    Language: Unknown
    Publisher: Termedia Sp. z.o.o.
    Publication Date: 2017
    detail.hit.zdb_id: 2203781-0
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  • 5
    Online Resource
    Online Resource
    Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C
    Walter de Gruyter GmbH ; 2018
    In:  LaboratoriumsMedizin Vol. 0, No. 0 ( 2018-12-04)
    Details
    In: LaboratoriumsMedizin, Walter de Gruyter GmbH, Vol. 0, No. 0 ( 2018-12-04)
    Abstract: Retinol-binding protein 4 (RBP4) and cystatin C are regarded as novel metabolic risk markers. Therefore, we aimed to examine which one of these biomarkers better correlates with metabolic syndrome (MetS) in a cohort of postmenopausal women. Methods A total of 129 postmenopausal women (among which 62 women had MetS) were recruited in this cross-sectional study. MetS was diagnosed according to the International Diabetes Federation criteria. Results Cystatin C and RBP4 levels were significantly higher in women with MetS, compared to those without MetS (p=0.011 vs. p 〈 0.001, respectively). A significant difference in the proportion of women with and without MetS across cystatin C and RBP4 quartiles was observed (χ 2 =5.1, p=0.025, and χ 2 =11.1, p=0.001, respectively). Logistic regression analysis revealed a borderline significant relationship between cystatin C and MetS (p=0.066), but this significance disappeared after adjustment for age, inflammation level and duration of menopause (p=0.221). On the contrary, a significant relationship between RBP4 and MetS was observed not only without adjustment (p=0.009), but also even after adjustment for age, inflammation level and duration of menopause (p=0.006). Conclusions RBP4 better correlates with MetS than cystatin C in postmenopausal women.
    Type of Medium: Online Resource
    ISSN: 1439-0477 , 0342-3026
    URL: Article
    DOI: 10.1515/labmed-2018-0042
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2018
    detail.hit.zdb_id: 2081704-6
    detail.hit.zdb_id: 2909042-8
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes
    Termedia Sp. z.o.o. ; 2020
    In:  Archives of Medical Science Vol. 16, No. 1 ( 2020), p. 42-50
    Details
    In: Archives of Medical Science, Termedia Sp. z.o.o., Vol. 16, No. 1 ( 2020), p. 42-50
    Type of Medium: Online Resource
    ISSN: 1734-1922
    URL: Article
    DOI: 10.5114/aoms.2019.87541
    Language: Unknown
    Publisher: Termedia Sp. z.o.o.
    Publication Date: 2020
    detail.hit.zdb_id: 2203781-0
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  • 7
    Online Resource
    Online Resource
    Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-1-27), p. 1-9
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-1-27), p. 1-9
    Abstract: Different byproducts of oxidative stress do not always lead to the same conclusion regarding its relationship with cardiometabolic risk, since controversial results are reported so far. The aim of the current study was to examine prooxidant determinant ((prooxidant-antioxidant balance (PAB)) and the marker of antioxidant defence capacity (total sulphydryl groups (tSHG)), as well as their ratio (PAB/tSHG) in relation to different cardiometabolic risk factors in the cohort of adult population. Additionally, we aimed to examine the joint effect of various cardiometabolic parameters on these markers, since to our knowledge, there are no studies that investigated that issue. A total of 292 participants underwent anthropometric measurements and venipuncture procedure for cardiometabolic risk factors assessment. Waist-to-height ratio (WHtR), body mass index, visceral adiposity index (VAI), and lipid accumulation product (LAP) were calculated. Principal component analysis (PCA) grouped various cardiometabolic risk parameters into different factors. This analysis was used in the subsequent binary logistic regression analysis to estimate the predictive potency of the factors towards the highest PAB and tSHG values. Our results show that triglycerides, VAI, and LAP were positively and high density lipoprotein cholesterol (HDL-c) were negatively correlated with tSHG levels and vice versa with PAB/tSHG index, respectively. On the contrary, there were no independent correlations between each cardiometabolic risk factor and PAB. PCA revealed that obesity-renal function-related factor (i.e., higher WHtR, but lower urea and creatinine) predicts both high PAB ( OR = 1.617 , 95% CI (1.204-2.171), P 〈 0.01 ) and low tSHG values ( OR = 0.443 , 95% CI (0.317-0.618), P 〈 0.001 ), while obesity-dyslipidemia-related factor (i.e., lower HDL-c and higher triglycerides, VAI, and LAP) predicts high tSHG values ( OR = 2.433 , 95% CI (1.660-3.566), P 〈 0.001 ). In conclusion, unfavorable cardiometabolic profile was associated with higher tSHG values. Further studies are needed to examine whether increased antioxidative capacity might be regarded as a compensatory mechanism due to free radicals’ harmful effects.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/6661940
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
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  • 8
    Online Resource
    Online Resource
    Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C
    Walter de Gruyter GmbH ; 2019
    In:  Journal of Laboratory Medicine Vol. 43, No. 1 ( 2019-02-25), p. 29-34
    Details
    In: Journal of Laboratory Medicine, Walter de Gruyter GmbH, Vol. 43, No. 1 ( 2019-02-25), p. 29-34
    Abstract: Retinol-binding protein 4 (RBP4) and cystatin C are regarded as novel metabolic risk markers. Therefore, we aimed to examine which one of these biomarkers better correlates with metabolic syndrome (MetS) in a cohort of postmenopausal women. Methods A total of 129 postmenopausal women (among which 62 women had MetS) were recruited in this cross-sectional study. MetS was diagnosed according to the International Diabetes Federation criteria. Results Cystatin C and RBP4 levels were significantly higher in women with MetS, compared to those without MetS (p=0.011 vs. p 〈 0.001, respectively). A significant difference in the proportion of women with and without MetS across cystatin C and RBP4 quartiles was observed (χ 2 =5.1, p=0.025, and χ 2 =11.1, p=0.001, respectively). Logistic regression analysis revealed a borderline significant relationship between cystatin C and MetS (p=0.066), but this significance disappeared after adjustment for age, inflammation level and duration of menopause (p=0.221). On the contrary, a significant relationship between RBP4 and MetS was observed not only without adjustment (p=0.009), but also even after adjustment for age, inflammation level and duration of menopause (p=0.006). Conclusions RBP4 better correlates with MetS than cystatin C in postmenopausal women.
    Type of Medium: Online Resource
    ISSN: 2567-9449 , 2567-9430
    URL: Article
    DOI: 10.1515/labmed-2018-0325
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2019
    detail.hit.zdb_id: 2909042-8
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  • 9
    Online Resource
    Online Resource
    Is endocan a novel potential biomarker of liver steatosis and fibrosis?
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2019
    In:  Journal of Medical Biochemistry Vol. 0, No. 0 ( 2019-11-21)
    Details
    In: Journal of Medical Biochemistry, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 0, No. 0 ( 2019-11-21)
    Abstract: Studies that evaluated endocan levels in nonalcoholic fatty liver disease (NAFLD) and liver fibrosis are scarce. We aimed to explore endocan levels in relation to different stages of liver diseases, such as NAFLD, as determined with fatty liver index (FLI) and liver fibrosis, as assessed with BARD score. Methods A total of 147 participants with FLI≥60 were compared with 64 participants with FLI 〈 30. An FLI score was calculated using waist circumference, body mass index, gamma-glutamyl transferase and triglycerides. Patients with FLI≥60 were further divided into those with no/mild fibrosis (BARD score 0–1 point; n=23) and advanced fibrosis (BARD score 2–4 points; n=124). BARD score was calculated as follows: diabetes mellitus (1 point) + body mass index≥28 kg/m 2 (1 point) + aspartate amino transferase/alanine aminotransferase ratio≥0.8 (2 points). Results Endocan was independent predictor for FLI and BARD score, both in univariate [OR=1.255 (95% CI= 1.104–1.426), P=0.001; OR=1.208 (95% CI=1.029– 1.419), P=0.021, respectively] and multivariate binary logistic regression analysis [OR=1.287 (95% CI=1.055– 1.570), P=0.013; OR=1.226 (95% CI=1.022–1.470), P=0.028, respectively] . Endocan as a single predictor showed poor discriminatory capability for steatosis/fibrosis [AUC=0.648; (95% CI=0.568–0.727), P=0.002; AUC= 0.667 (95% CI=0.555–0.778), P=0.013, respectively], whereas in a Model, endocan showed an excellent clinical accuracy [AUC=0.930; (95% CI=0.886–0.975), P 〈 0.001, AUC=0.840 (95% CI=0.763–0.918), P 〈 0.001, respectively]. Conclusions Endocan independently correlated with both FLI and BARD score. However, when tested in models (with other biomarkers), endocan showed better discriminatory ability for liver steatosis/fibrosis, instead of its usage as a single biomarker.
    Type of Medium: Online Resource
    ISSN: 1452-8266
    URL: Article
    DOI: 10.2478/jomb-2019-0042
    Language: Unknown
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2019
    detail.hit.zdb_id: 2405112-3
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  • 10
    Online Resource
    Online Resource
    Influence of obesity on serum uric acid level in postmenopausal women
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2016
    In:  Timocki medicinski glasnik Vol. 41, No. 1 ( 2016), p. 20-26
    Details
    In: Timocki medicinski glasnik, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 41, No. 1 ( 2016), p. 20-26
    Type of Medium: Online Resource
    ISSN: 0350-2899
    URL: Article
    DOI: 10.5937/tmg1601020K
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2016
    detail.hit.zdb_id: 2433190-9
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