In:
Journal of Psychopharmacology, SAGE Publications, Vol. 18, No. 4 ( 2004-12), p. 484-495
Abstract:
Using a novel procedure, the regulation of individual topographies of orofacial movement in the mouse by oppositional versus cooperative/synergistic D 1 -like: D 2 -like dopamine receptor interactions was studied. The D 1 -like agonists SK & F 38393 and SK & F 83959 each induced vertical, but not horizontal, jaw movements, together with tongue protrusions and incisor chattering; however, SK & F 82958 induced a different profile which, consistent with other neurochemical and neurophysiological studies, suggests that this agent shows anomalous properties relative to other D 1 -like agonists. When given alone, the D 2 -like agonist quinpirole reduced horizontal jaw movements and incisor chattering. On coadministration, both SK & F 38393- and SK & F 83959-induced vertical jaw movements and tongue protrusions were inhibited by quinpirole, while SK & F 82958 again showed an anomalous profile. These findings indicate that, in the mouse, vertical jaw movements and tongue protrusions are regulated by oppositional D 1 -like: D 2 -like interactions, and appear to involve a D 1 -like receptor that is not coupled to adenylyl cyclase, whereas horizontal jaw movements are inhibited by D 2 -like receptors. Additionally, results obtained using SK & F 82958 as a probe for D 1 -like mechanisms should be treated with considerable caution until they are confirmed using other D 1 -like agonists.
Type of Medium:
Online Resource
ISSN:
0269-8811
,
1461-7285
DOI:
10.1177/026988110401800405
Language:
English
Publisher:
SAGE Publications
Publication Date:
2004
detail.hit.zdb_id:
2028926-1
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