In:
Contrast Media & Molecular Imaging, Wiley, Vol. 5, No. 4 ( 2010-07), p. 231-236
Abstract:
An important challenge in medical diagnostics is to design all‐in‐one contrast agents that can be detected with multiple techniques such as magnetic resonance imaging (MRI), X‐ray computed tomography (CT), positron emission tomography (PET), single photon emission tomography (SPECT) or fluorescence imaging (FI). Although many dual labeled agents have been proposed, mainly for combined MRI/FI, constructs for three imaging modalities are scarce. Here gold/silica nanoparticles with a poly(ethylene glycol), paramagnetic and fluorescent lipid coating were synthesized, characterized and applied as trimodal contrast agents to allow for nanoparticle‐enhanced imaging of macrophage cells in vitro via MRI, CT and FI, and mice livers in vivo via MRI and CT. This agent can be a useful tool in a multitude of applications, including cell tracking and target‐specific molecular imaging, and is a step in the direction of truly multi‐modal imaging. Copyright © 2010 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
1555-4309
,
1555-4317
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
2222967-X
Permalink