In:
FEBS Letters, Wiley, Vol. 443, No. 1 ( 1999-01-22), p. 25-30
Kurzfassung:
Sphingosine 1‐phosphate (S1P) induces phospholipase C (PLC) activation and Ca 2+ mobilization in many types of cells. We examined the possible involvement of Edg‐3, one of the putative S1P receptors, in the phospholipase C (PLC)‐Ca 2+ system. S1P increased the cytoplasmic free Ca 2+ concentration without detectable inositol phosphate production in vector‐transfected CHO cells. In the Edg‐3‐transfected cells, however, the S1P‐induced Ca 2+ response was clearly enhanced, which was associated with a significant production of inositol phosphate. These S1P‐induced responses in the Edg‐3‐transfected cells were inhibited by U73122, a potent PLC inhibitor. We conclude that Edg‐3 may be one of the S1P receptors participating in the activation of the PLC‐Ca 2+ system.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(98)01676-7
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1999
ZDB Id:
1460391-3
SSG:
12
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