In:
American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 66, No. 11 ( 2005-11-01), p. 1907-1913
Abstract:
Objective —To determine the effects of short-term IV
administration of hydrocortisone or equine growth hormone (eGH) or long-term IM administration of eGH to
horses on tissue sensitivity to exogenous insulin. Animals —5 Standardbreds and 4 Dutch Warmblood
horses. Procedure —The euglycemic-hyperinsulinemic clamp
technique was used to examine sensitivity of peripheral tissues to exogenous insulin 24 hours after
administration of a single dose of hydrocortisone (0.06 mg/kg), eGH (20 µg/kg), or saline (0.9% NaCl)
solution and after long-term administration (11 to 15 days) of eGH to horses. The amounts of metabolized
glucose (M) and plasma insulin concentration (I) were determined. Results —Values for M and the M-to-I ratio were significantly
higher 24 hours after administration of a single dose of hydrocortisone than after single-dose administration
of eGH or saline solution. After long-term administration of eGH, basal I concentration was increased
and the mean M-to-I ratio was 22% lower, compared with values for horses treated with saline solution. Conclusions and Clinical Relevance —Increases in
M and the M-to-I ratio after a single dose of hydrocortisone imply that short-term hydrocortisone treatment
increases glucose use by, and insulin sensitivity of, peripheral tissues. Assuming a single dose of
hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for
use in reducing insulin resistance in peripheral tissues of horses with several disease states. In contrast,
long-term administration of eGH decreased tissue sensitivity to exogenous insulin associated with
hyperinsulinemia. Therefore, increased concentrations of growth hormone may contribute to insulin
resistance in horses with various disease states. ( Am J Vet Res 2005;66:1907–1913)
Type of Medium:
Online Resource
ISSN:
0002-9645
DOI:
10.2460/ajvr.2005.66.1907
Language:
Unknown
Publisher:
American Veterinary Medical Association (AVMA)
Publication Date:
2005
detail.hit.zdb_id:
2056942-7
SSG:
22
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