In:
Psychophysiology, Wiley, Vol. 57, No. 1 ( 2020-01)
Abstract:
Integrating genetic, epigenetic, and gene set enrichment analyses, while accounting for the environmental factor traumatic load, we identified stress‐ and memory‐associated neurogenic locus notch homolog protein (NOTCH) genes and related gene sets as potential risk mediators for the development of posttraumatic stress disorder (PTSD) after trauma. Thus, our results strengthen the presumed role of memory‐ and inflammation‐associated genes in PTSD development, and revealed a promising target for future treatment studies. Furthermore, we demonstrated the importance of traumatic load in PTSD etiology, and of an integrated approach in order to obtain a more comprehensive understanding of the functionality of PTSD‐associated markers.
Type of Medium:
Online Resource
ISSN:
0048-5772
,
1469-8986
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1484299-3
SSG:
5,2
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