In:
Hepatology Research, Wiley, Vol. 45, No. 10 ( 2015-10)
Abstract:
Treatment strategies for hepatocellular carcinoma (HCC) have been advanced. The aim of this study was to compare the change of the prognosis between hepatitis B‐related HCC (B‐HCC) and hepatitis C‐related HCC (C‐HCC) in the last two decades. Methods We enrolled 166 B‐HCC patients who underwent percutaneous ablation between 1990 and 2009. Patients were divided into three groups according to the treatment time period: 1990–1995 (cohort 1, n = 19), 1996–2002 (cohort 2, n = 49) and 2003–2009 (cohort 3, n = 98). We enrolled 1219 C‐HCC patients who underwent percutaneous ablation during the same period ( n = 190, 413 and 616, respectively.). Interferon and nucleoside/nucleotide analog use was investigated. Prognosis was evaluated for each cohort using the Kaplan–Meier method and a multivariate Cox proportional hazard regression model. Results Two (11%), 24 (49%) and 80 (82%) B‐HCC patients received nucleoside/nucleotide analogs during the follow‐up period in cohorts 1–3, respectively. Among them 1, 18 and 62 patients achieved viral remission, respectively. Thirty‐four (18%), 35 (8%) and 84 (14%) C‐HCC patients received interferon therapy, respectively. The 5‐year B‐HCC ( P 〈 0.001) survival rates were 52.6%, 61.1% and 81.6% for cohorts 1–3, respectively. However, the survival rates were 55.6%, 58.8% and 61.1% for C‐HCC ( P = 0.12), respectively. The B‐HCC prognosis improved dramatically ( P 〈 0.001) over time, whereas the prognosis of C‐HCC improved moderately ( P = 0.01). Conclusion The prognosis of B‐HCC has improved dramatically over time, whereas that of C‐HCC has improved moderately.
Type of Medium:
Online Resource
ISSN:
1386-6346
,
1872-034X
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2006439-1
detail.hit.zdb_id:
1387041-5
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