In:
Digestion, S. Karger AG, Vol. 79, No. 1 ( 2009), p. 44-51
Kurzfassung:
〈 i 〉 Background and Aims: 〈 /i 〉 Small intestinal toxicity of low-dose aspirin remains unclear. The purpose of this capsule endoscopy study was to assess the incidence of small bowel injury in healthy volunteers treated with short-term low-dose aspirin. 〈 i 〉 Methods: 〈 /i 〉 Healthy subjects were randomly assigned to receive low-dose aspirin for 14 days (Aspirin group) or no drugs for 14 days (Control group). The two treatment occasions were separated by a washout period of at least 4 weeks. All subjects underwent capsule endoscopy at the end of each treatment period. 〈 i 〉 Results: 〈 /i 〉 After 2 weeks of treatment, the percentages of subjects with small bowel pathology were 80% in the Aspirin group compared with 20% in the Control group (p = 0.023). The incidence of small bowel mucosal breaks in the Aspirin group was higher than that in the Control group, although the difference was not significant (30 vs. 0%; p = 0.210). 〈 i 〉 Conclusions: 〈 /i 〉 This is the first pilot study using capsule endoscopy to report on the relation between small bowel injury and low-dose aspirin. Among the healthy subjects, the short-term administration of low-dose aspirin was associated with a mild mucosal inflammation of the small bowel.
Materialart:
Online-Ressource
ISSN:
0012-2823
,
1421-9867
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2009
ZDB Id:
1482218-0
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