In:
Human Heredity, S. Karger AG, Vol. 48, No. 5 ( 1998), p. 271-274
Kurzfassung:
Atopic dermatitis (AD) is a chronic relapsing dermatitis which belongs to the group of atopy-related diseases as well as asthma and allergic rhinitis. As a probable genetic risk which may contribute to the organ specificity of AD, an association between AD and a genetic variant of the gene encoding mast cell chymase (MCC), which has chymotrypsin-like specificity and is abundant in skin mast cells, has been reported in a Japanese population. We tried to confirm the role of this polymorphism in the development of AD in a Japanese population. A case-control analysis using 100 AD patients and 101 controls did not show a significant difference in the frequency of the BB genotype between the patient and control groups (odds ratio 1.12, p = 0.81). The haplotype relative-risk analysis using 69 patient-parents trios did not suggest an association (χ 〈 sup 〉 2 〈 /sup 〉 = 0.177, p = 0.92). Thus, we failed to confirm the association between the polymorphism in the MCC gene and AD in the Japanese population.
Materialart:
Online-Ressource
ISSN:
0001-5652
,
1423-0062
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
1998
ZDB Id:
1482710-4
SSG:
12
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