In:
International Journal of Cancer, Wiley, Vol. 147, No. 7 ( 2020-10), p. 2007-2018
Abstract:
What's new? Angiopoietin‐2 (ANGPT2) is a prognostic factor in metastatic colorectal cancer (CRC). However, the molecular characterization of ANGPT2‐expressing CRC remains to be investigated. Here, using open source transcriptomic tools, the authors demonstrate that ANGT2‐expressing CRC is distributed across all Consortium Molecular Subtypes (CMS), and characterized by a poor prognosis and a specific gene expression pattern. ANGPT2 expression is not specifically related to a well‐defined molecular CRC entity. Beyond reflecting angiogenesis, genomic expression is associated with myeloid cell recruitment, invasion, stromal organization, and resistance to chemotherapy. A prognostic model was proposed using seric levels of ANGPT2, STC1, and CD138 in mCRC patients.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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