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  • Wiley  (4)
  • Kirsner, Robert S  (4)
  • 1
    Online Resource
    Online Resource
    Use of advanced technologies across the wound care spectrum: prologue
    Wiley ; 2016
    In:  International Wound Journal Vol. 13, No. S3 ( 2016-09), p. 5-7
    Details
    In: International Wound Journal, Wiley, Vol. 13, No. S3 ( 2016-09), p. 5-7
    Abstract: The growing trends of ageing populations and increasing prevalence of diabetes have given rise to an expanding number of problematic acute and chronic wounds. Over the past two decades, the use of negative pressure wound therapy ( NPWT ) with and without instillation of topical wound solutions has expanded to include treatment of a large variety of wounds. Additionally, the use of NPWT specifically designed for use over closed surgical incisions has been associated with favourable results. The recent introduction of an automated epidermal harvesting system, which neither creates a donor site wound nor requires the use of a surgeon, operating room or anaesthesia, has facilitated the use of epidermal grafting. This supplement highlights some of the advanced wound approaches that have been developed to address challenging wounds and the growing burden of wound care affecting both the patient and the health care system.
    Type of Medium: Online Resource
    ISSN: 1742-4801 , 1742-481X
    URL: Issue
    URL: Article
    DOI: 10.1111/iwj.2016.13.issue-S3
    DOI: 10.1111/iwj.12633
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2152163-3
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  • 2
    Online Resource
    Online Resource
    Human acellular dermal wound matrix: evidence and experience
    Wiley ; 2015
    In:  International Wound Journal Vol. 12, No. 6 ( 2015-12), p. 646-654
    Details
    In: International Wound Journal, Wiley, Vol. 12, No. 6 ( 2015-12), p. 646-654
    Abstract: A chronic wound fails to complete an orderly and timely reparative process and places patients at increased risk for wound complications that negatively impact quality of life and require greater health care expenditure. The role of extracellular matrix ( ECM ) is critical in normal and chronic wound repair. Not only is ECM the largest component of the dermal skin layer, but also ECM proteins provide structure and cell signalling that are necessary for successful tissue repair. Chronic wounds are characterised by their inflammatory and proteolytic environment, which degrades the ECM . Human acellular dermal matrices, which provide an ECM scaffold, therefore, are being used to treat chronic wounds. The ideal human acellular dermal wound matrix (HADWM) would support regenerative healing, providing a structure that could be repopulated by the body's cells. Experienced wound care investigators and clinicians discussed the function of ECM , the evidence related to a specific HADWM (Graftjacket ® regenerative tissue matrix, Wright Medical Technology, Inc., licensed by KCI USA , Inc., San Antonio, TX ), and their clinical experience with this scaffold. This article distills these discussions into an evidence‐based and practical overview for treating chronic lower extremity wounds with this HADWM.
    Type of Medium: Online Resource
    ISSN: 1742-4801 , 1742-481X
    URL: Issue
    URL: Article
    DOI: 10.1111/iwj.2015.12.issue-6
    DOI: 10.1111/iwj.12185
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2152163-3
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  • 3
    Online Resource
    Online Resource
    The use of keratin‐based wound products on refractory wounds
    Wiley ; 2016
    In:  International Wound Journal Vol. 13, No. 1 ( 2016-02), p. 110-115
    Details
    In: International Wound Journal, Wiley, Vol. 13, No. 1 ( 2016-02), p. 110-115
    Abstract: Keratin proteins have been shown to play a key role in wound healing. Controlled keratin gene ( KRT ) expression promotes cell growth, migration and differentiation, and as an example of the importance of keratin proteins, absence of KRT17 has been shown to delay wound closure. In addition, downregulation of KRT6 and KRT16 in non‐healing chronic venous ulcers suggests that deregulation of keratin expression contributes to non‐healing phenotype. A sample of 45 chronic wounds of mixed aetiologies presenting in 31 patients were treated with keratin‐based novel topical wound healing products. Thirty‐seven wounds or 82% of wounds were either healed or reduced in size of 〉 50% during treatment, with 29 (64%) healing completely and an additional 8 wounds experiencing 50% wound size reduction or greater. Of the wounds that responded, 15 required antimicrobial treatment during their course of treatment, suggesting that keratin dressing treatment should be interrupted briefly and then restarted when wound infection occur.
    Type of Medium: Online Resource
    ISSN: 1742-4801 , 1742-481X
    URL: Issue
    URL: Article
    DOI: 10.1111/iwj.2016.13.issue-1
    DOI: 10.1111/iwj.12245
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2152163-3
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  • 4
    Online Resource
    Online Resource
    Adalimumab treatment leads to reduction of tissue tumor necrosis factor‐alpha correlated with venous leg ulcer improvement: a pilot study
    Wiley ; 2016
    In:  International Wound Journal Vol. 13, No. 5 ( 2016-10), p. 963-966
    Details
    In: International Wound Journal, Wiley, Vol. 13, No. 5 ( 2016-10), p. 963-966
    Abstract: Venous leg ulcers ( VLUs ) have higher tumor necrosis factor‐α ( TNF ‐α) levels compared with normal skin. Refractory VLUs of long duration have higher TNF ‐α levels compared with VLUs of shorter duration. As up to 75% of VLUs fail to heal with standard care, we sought to evaluate the role of anti‐ TNF ‐α therapy for patients with refractory VLUs . Evaluable data were obtained in four of five subjects with recalcitrant VLUs treated with 80 mg of subcutaneous adalimumab at week 0 and with 40 mg at week 2 along with compression therapy and were followed‐up for 6 weeks. Wound biopsies taken at weeks 0 and 4 were stained with anti‐ TNF ‐α antibodies. Average 4‐week percent wound size reduction was 20.5% ± 6.4%. Two patients had wound size reduction more than 25%, and their percent wound size reduction correlated to percent TNF ‐α staining score reductions ( P = 0.02, R 2 = 0.999). VLU TNF ‐α level decrease 4 weeks post‐adalimumab treatment correlated with wound healing.
    Type of Medium: Online Resource
    ISSN: 1742-4801 , 1742-481X
    URL: Issue
    URL: Article
    DOI: 10.1111/iwj.2016.13.issue-5
    DOI: 10.1111/iwj.12497
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2152163-3
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