In:
EMBO reports, EMBO, Vol. 12, No. 10 ( 2011-10), p. 1055-1061
Abstract:
R‐spondins are secreted proteins known to synergize with Wnt signalling. The authors now show that R‐spondins are ligands for LGR4 and LGR5 orphan G‐protein‐coupled receptors. Binding of R‐spondins to LGRs positively regulates both Wnt/ ‐catenin and Wnt/PCP signalling pathways in vivo.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.1038/embor.2011.175
Language:
English
Publisher:
EMBO
Publication Date:
2011
detail.hit.zdb_id:
2025376-X
SSG:
12
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