In:
Lipids, Wiley, Vol. 36, No. 4 ( 2001-04), p. 353-359
Abstract:
In this study, we examined the effects of fish oils on 5‐fluorouracil (5‐FU)‐induced antitumor activity in mice. First, we examined the antitumor activity of the oral administration of two fish oils (carp oil and tuna oil) in sarcoma 180‐bearing mice. Carp oil (0.2 and 0.4 mL/mouse) and tuna oil (0.2 and 0.4 mL/mouse) had no effects on tumor growth. Next, we examined the combined effects of 5‐FU plus two fish oils (carp oil and tuna oil) on the antitumor activity and side effects compared to the effects of 5‐FU alone (12.5 mg/kg/d). We found that carp oil (0.4 mL/mouse) or tuna oil (0.2 or 0.4 mL/mouse) enhanced the ability of 5‐FU (12.5 mg/kg/d) to prevent tumor growth, without increasing side effects such as myelotoxicity and immunocompetent organ toxicity. Tuna oil (0.2 mL/mouse) slightly reduced body weight as compared to the effects of 5‐FU alone and water alone (control). The area under the curve (AUC) (0–120 min) of blood 5‐FU levels was reduced by the oral co‐administration of 5‐FU with carp oil or tuna oil. Apparent T max was shortened by the oral co‐administration of 5‐FU with carp oil or tuna oil. On the other hand, AUC (0–4 h) of 5‐FU incorporation into tumor RNA fraction was not affected by the oral co‐administration of 5‐FU with carp oil or tuna oil.
Type of Medium:
Online Resource
ISSN:
0024-4201
,
1558-9307
DOI:
10.1007/s11745-001-0727-3
Language:
English
Publisher:
Wiley
Publication Date:
2001
detail.hit.zdb_id:
2030265-4
SSG:
12
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