In:
Annals of Gastroenterological Surgery, Wiley, Vol. 3, No. 5 ( 2019-09), p. 523-533
Abstract:
Effective multidisciplinary approaches for unresectable pancreatic cancer (UR‐PC) that include modern chemotherapeutic regimens and subsequent conversion surgery (CS) are being developed. The aim of this study was to evaluate outcomes of patients clinically diagnosed with UR ‐ PC , focusing on the efficacy of CS . Methods Patients ineligible for two multicenter phase II studies conducted by the Hokkaido Pancreatic Cancer Study Group (HOPS) were recruited. Sequential treatment regimens, conversion to radical surgery, and overall survival (OS) were analyzed by multidetector computed tomography ( MDCT )‐based UR factors. Univariate and multivariate analyses were performed to identify predictors of OS . Results Sixty‐six of 247 intended recruits for HOPS studies from October 2013 to April 2016 were included. Unresectability was due to locally advanced ( LA ) disease and metastasis (M) in 42 and 24 patients, respectively. Induction therapy began with chemotherapy (CT) and chemoradiotherapy ( CRT ) in 44 and 17 patients, respectively, of whom 23 received modern CT regimens. Radical surgery was completed in 12 ( LA , 10; M, two) with a median treatment interval of 10.3 months (range, 2‐32). Eleven patients (91.6%) achieved pathological R0 resection. Median OS was significantly longer in patients who underwent CS than those who did not (44.1 vs 14.5 months, P 〈 0.0001). CS was an independent predictor of OS (hazard ratio, 0.078; 95% confident interval, 0.017‐0.348; P = 0.001). Conclusion Conversion surgery after a favorable response to sequential treatment might prolong survival in patients with UR ‐ PC . Precise diagnosis on MDCT followed by sequential multimodal anticancer treatment is essential.
Type of Medium:
Online Resource
ISSN:
2475-0328
,
2475-0328
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2895706-4
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