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  • Wiley  (12)
  • Kim, Yu Kyeong  (12)
  • 11
    Online Resource
    Online Resource
    Circadian rest‐activity rhythm and longitudinal brain changes underlying late‐life cognitive decline
    Wiley ; 2023
    In:  Psychiatry and Clinical Neurosciences Vol. 77, No. 4 ( 2023-04), p. 205-212
    Details
    In: Psychiatry and Clinical Neurosciences, Wiley, Vol. 77, No. 4 ( 2023-04), p. 205-212
    Abstract: The neurobiological substrates underlying the relationship of circadian rest‐activity rhythm (RAR) alteration with accelerated late‐life cognitive decline are not clearly understood. In the present study, the longitudinal relationship of objectively measured circadian RAR with in vivo Alzheimer disease (AD) pathologies and cerebrovascular injury was investigated in older adults without dementia. Methods The present study included 129 participants without dementia who participated in the KBASE (Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease) cohort. All participants underwent actigraphy at baseline and two consecutive [ 11 C] Pittsburgh compound‐B positron emission tomography (PET), [ 18 F] fluorodeoxyglucose‐PET, magnetic resonance imaging, and Mini‐Mental State Examination (MMSE) at baseline and at a 2‐year follow‐up assessment. The associations of circadian RAR with annualized change in neuroimaging measures including global amyloid‐beta retention, AD‐signature region cerebral glucose metabolism (AD‐CM), and white matter hyperintensity volume were examined. Results Delayed acrophase at baseline was significantly associated with greater annualized decline of AD‐CM over a 2‐year period, but not with that of other neuroimaging measures. In contrast, other circadian RAR parameters at baseline had no association with annualized change of any neuroimaging measures. Annualized decline of AD‐CM was also significantly positively associated with the annual change in MMSE scores. Furthermore, a mediation analysis showed that greater reduction in AD‐CM mediated the effect of delayed acrophase at baseline on faster decline of MMSE score. Conclusion The findings indicate that delayed acrophase in late life may cause or predict hypometabolism at AD‐signature brain regions, which underlies cognitive decline in the near future.
    Type of Medium: Online Resource
    ISSN: 1323-1316 , 1440-1819
    URL: Issue
    URL: Article
    DOI: 10.1111/pcn.v77.4
    DOI: 10.1111/pcn.13521
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2010264-1
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  • 12
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    Regional microstructural alteration of the corpus callosum in preclinical Alzheimer’s disease : Neuroimaging / Optimal neuroimaging measures for early detection
    Wiley ; 2020
    In:  Alzheimer's & Dementia Vol. 16, No. S5 ( 2020-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 16, No. S5 ( 2020-12)
    Abstract: While previous studies consistently reported regional microstructural changes of the cerebral white matter (WM) in Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI), little information is available for such changes in the preclinical stage of AD. We first aimed to investigate regional microstructural alteration of the WM in cognitively normal (CN) older adults with amyloid‐beta (Aβ) deposition. We also tried to develop a prediction model for Aβ positivity in CN using information on WM microstructural alteration and clinical variables that can be easily obtained in memory clinics. Method Seventy‐five CN older adults from the Korean Brain Aging Study for the Early diagnosis and prediction of Alzheimer’s disease (KBASE) cohort were included in the analyses. All Participants underwent comprehensive clinical and neuropsychological assessment, T1 MRI, diffusion tensor imaging (DTI), and [ 11 C]PiB‐PET. All CN subjects were divided into Aβ positive (CN+) and negative (CN‐) based on the level of cerebral Aβ retention on [ 11 C]PiB‐PET. Multivariate stepwise logistic regression analyses were conducted to develop Aβ positivity prediction models. Result When compared to CN‐, CN+ showed high mean diffusivity (MD) value of the genu of the corpus callosum (CC_genu) (F(1,73) = 6.357, p = 0.014, Figure 1). The area under the curve (AUC) of the receiver operating characteristics curve for the Aβ positivity prediction model only using MD of the CC_genu was 0.653 [confidence interval (CI) = 0.511‐0.794]. Model with MD of the CC_genu, age, and word list recall and constructional recall test scores were finally selected. The AUC of the final model was 0.851 [CI = 0.765‐0.937] (Figure 2). Conclusion The findings indicate that microstructural alteration of the CC_genu occurs even in the stage of preclinical AD. When taken together with episodic memory scores commonly available in clinical practice, information about such regional WM microstructural alteration can be used to screen preclinical AD.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v16.S5
    DOI: 10.1002/alz.045000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2201940-6
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