In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2018-09-12)
Abstract:
Whether a sustained virological response (SVR) improves long-term outcomes in chronic hepatitis C patients with earlier-stage fibrosis has not been established. We investigated the differential effect of SVR on the risk of outcomes according to hepatic fibrosis grade. Fibrosis grade was categorised using FIB-4: 〈 1.45, low-probability of significant fibrosis; 1.45–3.25, intermediate-probability; and ≥3.25, high-probability. Primary and secondary endpoints were hepatocellular carcinoma (HCC) occurrence and death, respectively. Among 1,373 included chronic hepatitis C patients, 744 patients were treated with interferon-based or –free regimens and 622 (83.6%) achieved SVR. SVR was independently associated with lower risk of HCC ( vs . untreated: adjusted hazard ratio [aHR], 0.165; 95% confidence interval [CI] , 0.077–0.350; P 〈 0.001) and overall death ( vs . untreated; aHR, 0.146; 95% CI, 0.050–0.424; P 〈 0.001) during the median observation of 3.5 (interquartile range, 1.9–6.6) years. The SVR group had significantly lower risk of HCC than the untreated group among patients with intermediate-probability ( n = 492: aHR, 0.171; 95% CI, 0.051–0.578; P = 0.004) and high-probability ( n = 446: aHR, 0.243; 95% CI, 0.107–0.551; P 〈 0.001) of significant fibrosis. HRs were maintained after balancing with inverse probability weighting. SVR was associated with reduced risk of HCC development and all-cause mortality in patients with chronic hepatitis C.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-018-31839-y
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2018
detail.hit.zdb_id:
2615211-3
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