In:
International Journal of Cancer, Wiley, Vol. 134, No. 3 ( 2014-02), p. 519-529
Abstract:
What's new? Cancer stem cells (CSCs) may play a pivotal role in tumor recurrence and resistance to chemotherapy. For example, CSCs are enriched in residual tumors following conventional chemotherapy. In this study, the authors found that nonsteroidal anti‐inflammatory drugs (NSAIDs) could selectively reduce colon CSCs, by inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1, and activating PPARG. NSAIDs also suppressed chemotherapy‐induced increases of CSCs in a mouse xenograft model of colorectal cancer (CRC). NSAIDs may thus provide a promising adjunct to standard chemotherapy, decreasing tumor recurrence and improving survival in CRC.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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