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  • Wiley  (4)
  • Kim, Won Ho  (4)
  • Park, Soo Jung  (4)
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  • Wiley  (4)
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  • 1
    Online-Ressource
    Online-Ressource
    Comparison of clipping with and without epinephrine injection for the prevention of post‐polypectomy bleeding in pedunculated colon polyps
    Wiley ; 2015
    In:  Journal of Gastroenterology and Hepatology Vol. 30, No. 10 ( 2015-10), p. 1499-1506
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 30, No. 10 ( 2015-10), p. 1499-1506
    Kurzfassung: Post‐polypectomy bleeding ( PPB ) is the most common adverse event of colonoscopic polypectomy, especially in cases with large pedunculated polyps. To minimize the risk of PPB , several endoscopic preventive methods have been performed. The aim of this prospective, randomized study was to compare the rates of PPB following single (clipping alone) and combined (clipping plus epinephrine‐saline injection) methods in prevention of PPB in large pedunculated polyps. Methods Adult patients with pedunculated colorectal polyps with heads ≥ 10 mm were prospectively enrolled from M arch 2011 to J anuary 2013. Patients were randomized to receive treatment of either clips alone (group A) or clips plus injection of epinephrine‐saline (group B) prior to a conventional polypectomy. PPB rate in both groups were compared. Results A total of 148 patients with 173 pedunculated colorectal polyps were enrolled. Groups A and B each had 74 patients, with 83 and 90 polyps, respectively. The mean head diameters were 17.2 ± 6.6 and 17.5 ± 6.7 mm in groups A and B, respectively ( P  = 0.748). Immediate PPB ( IPPB ) occurred in 10 cases (12.0%) from group A and 13 cases (14.4%) from group B ( P  = 0.64). There were no cases of delayed PPB or perforation. Multivariate analysis showed that inadequate bowel preparation and large head diameter of polyp were independent risk factors for IPPB . Conclusions The rate of IPPB is relatively high in cases with large pedunculated polyps, but these polyps can be successfully resected by snare polypectomy following use of the single prophylactic clipping method.
    Materialart: Online-Ressource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2015.30.issue-10
    DOI: 10.1111/jgh.12994
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2015
    ZDB Id: 2006782-3
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    Fecal calprotectin as a non‐invasive biomarker for intestinal involvement of Behçet's disease
    Wiley ; 2017
    In:  Journal of Gastroenterology and Hepatology Vol. 32, No. 3 ( 2017-03), p. 595-601
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 32, No. 3 ( 2017-03), p. 595-601
    Kurzfassung: The diagnostic and prognostic values of fecal calprotectin (FC) levels in patients with inflammatory bowel diseases have been proven. However, little is known about the usefulness of FC measurement in predicting intestinal involvement of Behçet's disease (BD). Methods Forty‐four consecutive patients with systemic BD who underwent colonoscopy for the evaluation of gastrointestinal symptoms were prospectively enrolled between November 2012 and March 2014 in a single tertiary medical center. Fecal specimens from the patients were obtained the day before bowel cleansing and 3 months after colonoscopy. Results Twenty‐five patients showed intestinal ulcerations on colonoscopy (12 [48.0%] typical and 13 [52.0%] atypical ulcerations). The median FC level in the intestinal BD group was significantly higher than that in the non‐diagnostic group (112.53 [6.86–1604.39] vs 31.64 [5.46–347.60] µg/g, respectively, P  = 0.003). Moreover, the typical ulceration group showed a significantly higher median FC level than the atypical ulceration group in patients with intestinal BD (435.995 [75.65–1604.39] vs 71.42 [6.86–476.94] µg/g, respectively, P  = 0.033). Multivariate analysis revealed higher FC as an independent predictor of intestinal BD (OR = 38.776; 95% CI = 2.306–652.021; P  = 0.011). The cut‐off level of FC for predicting intestinal BD was 68.89 µg/g (76% sensitivity and 79% specificity). The absolute changes between fecal calprotectin levels and the disease activity index of intestinal BD from initial diagnosis of intestinal BD to 3 months after diagnosis were significantly correlated (Pearson's correlation coefficient = 0.470, P  = 0.027). Conclusion The FC level might serve as a non‐invasive surrogate marker of intestinal involvement of BD.
    Materialart: Online-Ressource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2017.32.issue-3
    DOI: 10.1111/jgh.13530
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2017
    ZDB Id: 2006782-3
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    IL‐6 and IL‐8, secreted by myofibroblasts in the tumor microenvironment, activate HES1 to expand the cancer stem cell population in early colorectal tumor
    Wiley ; 2021
    In:  Molecular Carcinogenesis Vol. 60, No. 3 ( 2021-03), p. 188-200
    Details
    In: Molecular Carcinogenesis, Wiley, Vol. 60, No. 3 ( 2021-03), p. 188-200
    Kurzfassung: Interaction between a tumor and its microenvironment is important for tumor initiation and progression. Cancer stem cells (CSCs) within the tumor interact with a microenvironmental niche that controls their maintenance and differentiation. We investigated the CSC‐promoting effect of factors released from myofibroblasts into the microenvironment of early colorectal cancer tumors and its molecular mechanism. By messenger RNA microarray analysis, expression of HES1, a Notch signaling target, significantly increased in Caco‐2 cells cocultured with 18Co cells (pericryptal myofibroblasts), compared to its expression in Caco‐2 cells cultured alone. Caco‐2 cells cultured in 18Co‐conditioned media (CM) showed a significant increase in CD133+CD44+ cells and HES1 expression compared to that in Caco‐2 cells cultured in regular media. Significant amounts of interleukin‐6 (IL‐6) and IL‐8 were detected in 18Co‐CM compared to levels in regular media. The 18Co‐CM‐induced increase in CD133+CD44+ cells was attenuated by IL‐6‐ and IL‐8‐neutralizing antibodies. Furthermore, these neutralizing antibodies and inhibitors of STAT3 and gamma‐secretase reduced the expression of HES1 induced in Caco‐2 cells cultured in 18Co‐CM. Immunohistochemical analysis of human tissues revealed that IL‐6, IL‐8, and HES1 expression increased from normal to adenoma, and from adenoma to cancer tissues. In addition, IL‐6 and HES1 expression was positively correlated in early colorectal cancer tissues. In conclusion, the increase of CSCs by myofibroblasts could be mediated by IL‐6/IL‐8‐induced HES1 activation in the tumor microenvironment. Based on these data, the IL‐6/IL‐8‐mediated Notch/HES1 and STAT3 pathway, through which CSCs interact with their microenvironment, might be a potential target for the prevention and treatment of colorectal tumors.
    Materialart: Online-Ressource
    ISSN: 0899-1987 , 1098-2744
    URL: Issue
    URL: Article
    DOI: 10.1002/mc.v60.3
    DOI: 10.1002/mc.23283
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2001984-1
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 4
    Online-Ressource
    Online-Ressource
    Rediscover the clinical value of small intestinal bacterial overgrowth in patients with intestinal Behçet's disease
    Wiley ; 2018
    In:  Journal of Gastroenterology and Hepatology Vol. 33, No. 2 ( 2018-02), p. 375-379
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 33, No. 2 ( 2018-02), p. 375-379
    Kurzfassung: Many patients with intestinal Behçet's disease (BD) still suffer from gastrointestinal symptoms despite the disease being in endoscopic or radiological remission. Previous studies report that small intestinal bacterial overgrowth (SIBO) can be associated with inflammatory bowel disease. However, there have been no reports about SIBO in patients with intestinal BD. We sought to identify the frequency of SIBO in patients with inactive intestinal BD by hydrogen breath test (HBT) and to investigate the efficacy of rifaximin as a treatment for SIBO. Methods Twenty‐five patients with intestinal BD who had gastrointestinal symptoms even in endoscopic or radiological remission status were enrolled between January 2012 and January 2016. The patients filled out a questionnaire regarding their subjective gastrointestinal symptoms and took an HBT. Patients with positive HBT results were recommended to take 800‐mg rifaximin daily for 14 days. Results Nine patients (9/25, 36%) had a positive HBT test. Eight (8/9, 88.9%) were women, and their mean age was 48.7 years. The most common symptom was abdominal distension (8/9, 88.9%), followed by abdominal discomfort (6/9, 66.7%). Rifaximin was prescribed to the nine patients with positive HBT, but two patients refused to take the medication. Four weeks later, six of the seven patients taking rifaximin (85.7%) reported symptom improvement, and none of them reported adverse events. Conclusions More than one‐third of the patients with inactive intestinal BD who had gastrointestinal symptoms were accompanied by SIBO using HBT. Rifaximin might be an effective and safe drug to treat these patients.
    Materialart: Online-Ressource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2018.33.issue-2
    DOI: 10.1111/jgh.13855
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2018
    ZDB Id: 2006782-3
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
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