In:
Disease Markers, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
Abstract:
Background . To investigate the clinical significance of the perioperative CA19-9 change for predicting survival in intrahepatic cholangiocarcinoma (ICC) patients treated with surgical resection. Methods . We retrospectively reviewed the data from 74 ICC patients treated with surgical resection between April 2001 and July 2010. Perioperative CA19-9 (preoperative level, postoperative lowest level, and level at recurrence) levels were analyzed for patient distribution and survival. Results . Before surgery, there were 45 patients who had high preoperative CA19-9 levels ( 〉 37 U/mL) and 29 who had normal levels (≤37 U/mL). Of 45 patients with high CA19-9 levels, 34 had normalized CA19-9 levels after resection and 11 had persistently high levels. Of 34 patients with normalized CA19-9 levels, 18 showed recurrence. Of 29 patients with normal preoperative levels, 15 showed recurrence. Multivariate analysis presented that old age (hazard ratio [HR] = 3.881, p 〈 0.01 ), persistently high postoperative CA19-9 level (HR = 4.41, p 〈 0.001 ), perineural invasion (HR = 3.073, p = 0.01 ), narrow resection margin (HR = 3.152, p = 0.05 ), and lymph node metastasis (HR = 3.427, p = 0.02 ) were significant independent risk factors for survival. Conclusions . Patients who have normalized CA19-9 levels postoperatively have longer survival outcomes. Therefore, normalized postoperative CA19-9 may be a useful clinical marker for ICC survival.
Type of Medium:
Online Resource
ISSN:
0278-0240
,
1875-8630
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2015
detail.hit.zdb_id:
2033253-1
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