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  • 1
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    Online Resource
    The usefulness of the estimated average glucose/fasting blood glucose ratio for pancreatic β‐cell function assessment in hyperglycemia during health checkups
    Wiley ; 2022
    In:  Journal of Clinical Laboratory Analysis Vol. 36, No. 10 ( 2022-10)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 36, No. 10 ( 2022-10)
    Abstract: Type 2 diabetes (T2DM) is a disease marked by inadequate insulin secretion by pancreatic beta‐cell function (BCF) failure and insulin resistance (IR). Assessing and managing the BCF and IR should be started early to prevent or delay the progression of the disease. The aim of this study was to determine the usefulness of the estimated average glucose (eAG)/fasting blood glucose (FBG) ratio for pancreatic BCF in hyperglycemia. Methods This cross‐sectional study consecutively selected 10,594 subjects who underwent a health checkup at 16 health checkup centers in 13 Korean cities between 2019 and 2021. The subjects consisted of 3003 patients with normoglycemia, 3413 with impaired fasting glucose and 4178 with T2DM. The eAG was calculated using Nathan's regression equation. BCF and IR were estimated by the homeostasis model assessment (HOMA)‐β and HOMA‐IR, respectively. Multivariate (adjusted) regression analysis was performed to evaluate the association between the eAG/FBG ratio and HOMA. Results The median values among FBG groups for the eAG/FBG ratio, HOMA‐β, ‐IR and insulin differed significantly ( p   〈  0.001). The second‐, third‐ and fourth‐quartile groups of the eAG/FBG ratio had positive higher correlation coefficients [9.533, 10.080 and 12.021, respectively (all p   〈  0.001)] for HOMA‐β than the first quartile group, and higher negative coefficients for HOMA‐IR [−0.696, −0.727 and −0.598, respectively (all p  = 0.001)]. Conclusion The eAG/FBG ratio was significantly correlated with both HOMA‐β and ‐IR, which suggests that eAG/FBG ratio reveals BCF and IR in hyperglycemia. Measurement of this ratio could be useful for monitoring BCF and IR in prediabetes and T2DM.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v36.10
    DOI: 10.1002/jcla.24693
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2001635-9
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  • 2
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    Diagnostic performance of Mac‐2 binding protein glycosylation isomer (M2BPGi) in screening liver fibrosis in health checkups
    Wiley ; 2020
    In:  Journal of Clinical Laboratory Analysis Vol. 34, No. 8 ( 2020-08)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 34, No. 8 ( 2020-08)
    Abstract: Mild‐to‐moderate fibrosis is rarely diagnosed because the disease is asymptomatic in the early stage. The serum level of Mac‐2 binding protein glycosylation isomer (M2BPGi) has been found to increase with the severity of liver fibrosis. The aim of this study was to determine the diagnostic performance of M2BPGi in screening liver fibrosis using magnetic resonance elastography (MRE) as a reference standard and to compare it with using the aspartate aminotransferase‐to‐platelet ratio (APRI) and the Fibrosis‐4 index (FIB‐4) in health checkups. Methods This cross‐sectional study consecutively selected subjects at health examinations who underwent MRE and M2BPGi testing at eight health promotion centers in Korea between January and September 2019. The serum M2BPGi level was measured using the chemiluminescence enzyme immunoassay method. The measured levels were indexed using the cutoff index (COI). COI values of M2BPGi were compared with the MRE results. Results The median (interquartile) values of COI for fibrosis stages F0 (normal liver stiffness), F1 (mild fibrosis), F2 (significant fibrosis), and ≥F3 (advanced fibrosis) were 0.49 (0.34‐0.61), 0.48 (0.38‐0.68), 0.64 (0.43‐1.03), and 1.01 (0.75‐1.77), respectively ( P   〈  .0001). The AUCs of the COI for the screening of fibrosis stage ≥F1, ≥F2, and ≥F3 were 0.591, 0.698, and 0.853, respectively. Using a threshold of 0.75 for COI to exclude advanced fibrosis had a sensitivity, specificity, and negative predictive value of 80.0%, 77.9%, and 98.9%, respectively. The AUC for excluding advanced fibrosis was better for M2BPGi than for FIB‐4 and APRI. Conclusion Serum M2BPGi was useful for screening significant and advanced fibrosis in health checkups.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v34.8
    DOI: 10.1002/jcla.23316
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2001635-9
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  • 3
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    Associations of complete blood count parameters with pancreatic beta‐cell function and insulin resistance in prediabetes and type 2 diabetes mellitus
    Wiley ; 2022
    In:  Journal of Clinical Laboratory Analysis Vol. 36, No. 6 ( 2022-06)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 36, No. 6 ( 2022-06)
    Abstract: Previous studies found controversial associations of CBC parameters with pancreatic beta‐cell function (BCF) and insulin resistance (IR). The aim of this was to determine the independent associations of CBC parameters with BCF and IR in prediabetes and type 2 diabetes mellitus (T2DM). Methods This study selected subjects who underwent health checkups at 16 health‐promotion centers in 13 Korean cities during 2021. The subjects comprised 1470 patients with normoglycemia, 1124 with prediabetes, and 396 with T2DM. BCF and IR were assessed using the homeostasis model assessment (HOMA)‐β and HOMA‐IR, respectively. Correlation and multiple linear regression analyses were used to determine the correlation between CBC parameters and HOMA. Results While HOMA‐IR gradually increased according to red blood cell count quartiles (1.22, 1.40, 1.47, and 1.91, in the first, second, third, and fourth quartiles, respectively; p 〈 0.001), there was no correlation after adjusting for waist circumference (WC) and HbA1c. The red blood cell distribution width (RDW) was associated with HOMA‐ β [coefficient ( β ) = 15.527, p = 0.002], but not with HOMA‐IR. White blood cells (WBCs) were associated with HOMA‐IR and HOMA‐ β , which was stronger in HOMA‐β ( β = 0.505 vs 15.171, p = 0.002) after adjusting for WC and HbA1c. The platelet count was correlated with HOMA‐IR and HOMA‐β, which only remained in HOMA‐β ( β = 15.581, p = 0.002) after adjusting for WC and HbA1c. Conclusion RDW, WBC, and platelet counts were independently associated with only HOMA‐β in prediabetes and T2DM. This suggests that these CBC parameters could represent BCF in prediabetes and T2DM.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v36.6
    DOI: 10.1002/jcla.24454
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 4
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    SARS-CoV-2 Antibody Response and Sustainability after a Third Dose of BNT162b2 in Healthcare Workers at Health Promotion Centers
    MDPI AG ; 2023
    In:  Viruses Vol. 15, No. 3 ( 2023-03-14), p. 751-
    Details
    In: Viruses, MDPI AG, Vol. 15, No. 3 ( 2023-03-14), p. 751-
    Abstract: The aim of this study was to determine the antibody response and the sustainability of immunogenicity after a third dose of BNT162b2 (BNT) in homologous [ChAdOx1 (ChAd)/ChAd, BNT/BNT, and mRNA-1273 (Moderna)/Moderna] and heterologous (ChAd/BNT) vaccinations of two primary doses with different schemes. This prospective observational study recruited consenting healthcare workers from 16 healt h checkup centers in 13 Korean cities. Three-point blood tests were analyzed as the antibody response after the third vaccination: T3-1 (1 month after the third dose), T3-3 (3 months after the third dose), and T3-4–10 (4–10 months after the third dose). SARS-CoV-2 antibodies were measured using a chemiluminescence microparticle immunoassay with SARS-CoV-2 IgG II Quant in the ARCHITECT system (Abbott Diagnostics). The antibody levels were significantly higher in the Moderna /Moderna and BNT/BNT groups than in the ChAd/ ChAd and ChAd/BNT groups (p 〈 0.05) at T3-1. At T3-3, antibody levels had decreased by 29.1% in the BNT/BNT group and by 45.3% in the ChAd/ChAd group compared with the antibody levels at T3-1. The anti-SARS-CoV-2 S-RBD IgG levels at T3-1 were significantly associated with having received mRNA vaccines as the two primary doses (p 〈 0.001). The third dose of BNT induced an increased humoral immune response in various vaccination schemes, which was more prominent for the two primary doses of homologous mRNA vaccines. However, this immunogenicity decreased within 3–10 months after the third dose. These results suggest that another booster dose (a fourth dose), which would be able to counteract SARS-CoV-2 variants, is needed.
    Type of Medium: Online Resource
    ISSN: 1999-4915
    URL: Article
    DOI: 10.3390/v15030751
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2516098-9
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  • 5
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    The patterns of lifestyle, metabolic status, and obesity among hypertensive patients in Korea: a latent class analysis
    Korean Society of Epidemiology ; 2020
    In:  Epidemiology and Health ( 2020-08-31), p. e2020061-
    Details
    In: Epidemiology and Health, Korean Society of Epidemiology, ( 2020-08-31), p. e2020061-
    Type of Medium: Online Resource
    ISSN: 2092-7193
    URL: Article
    DOI: 10.4178/epih.e2020061
    Language: English
    Publisher: Korean Society of Epidemiology
    Publication Date: 2020
    detail.hit.zdb_id: 2590698-7
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  • 6
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    Association between Smoking, Metabolic Syndrome, and Arteriosclerosis in Korean Men
    The Korean Society of Health Informatics and Statistics ; 2016
    In:  Journal of Health Informatics and Statistics Vol. 41, No. 1 ( 2016-02-29), p. 18-26
    Details
    In: Journal of Health Informatics and Statistics, The Korean Society of Health Informatics and Statistics, Vol. 41, No. 1 ( 2016-02-29), p. 18-26
    Type of Medium: Online Resource
    ISSN: 2465-8014 , 2465-8022
    URL: Article
    DOI: 10.21032/jhis.2016.41.1.18
    Language: English
    Publisher: The Korean Society of Health Informatics and Statistics
    Publication Date: 2016
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  • 7
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    Prevalence of Comorbidities among Patients with Diabetes
    The Korean Society of Health Informatics and Statistics ; 2018
    In:  Journal of Health Informatics and Statistics Vol. 43, No. 3 ( 2018-08-31), p. 237-244
    Details
    In: Journal of Health Informatics and Statistics, The Korean Society of Health Informatics and Statistics, Vol. 43, No. 3 ( 2018-08-31), p. 237-244
    Type of Medium: Online Resource
    ISSN: 2465-8014 , 2465-8022
    URL: Article
    DOI: 10.21032/jhis.2018.43.3.237
    Language: English
    Publisher: The Korean Society of Health Informatics and Statistics
    Publication Date: 2018
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  • 8
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    Comparison of Traditional and Reverse Syphilis Screening Algorithms in Medical Health Checkups
    Annals of Laboratory Medicine ; 2017
    In:  Annals of Laboratory Medicine Vol. 37, No. 6 ( 2017-11-01), p. 511-515
    Details
    In: Annals of Laboratory Medicine, Annals of Laboratory Medicine, Vol. 37, No. 6 ( 2017-11-01), p. 511-515
    Type of Medium: Online Resource
    ISSN: 2234-3806 , 2234-3814
    URL: Article
    DOI: 10.3343/alm.2017.37.6.511
    Language: English
    Publisher: Annals of Laboratory Medicine
    Publication Date: 2017
    detail.hit.zdb_id: 2677441-0
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  • 9
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    Complete Blood Count Reference Intervals and Patterns of Changes Across Pediatric, Adult, and Geriatric Ages in Korea
    Annals of Laboratory Medicine ; 2018
    In:  Annals of Laboratory Medicine Vol. 38, No. 6 ( 2018-11-28), p. 503-511
    Details
    In: Annals of Laboratory Medicine, Annals of Laboratory Medicine, Vol. 38, No. 6 ( 2018-11-28), p. 503-511
    Type of Medium: Online Resource
    ISSN: 2234-3806 , 2234-3814
    URL: Article
    DOI: 10.3343/alm.2018.38.6.503
    Language: English
    Publisher: Annals of Laboratory Medicine
    Publication Date: 2018
    detail.hit.zdb_id: 2677441-0
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  • 10
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    Plasma NT-proBNP levels associated with cardiac structural abnormalities in asymptomatic health examinees with preserved ejection fraction: a retrospective cross-sectional study
    BMJ ; 2019
    In:  BMJ Open Vol. 9, No. 4 ( 2019-04), p. e026030-
    Details
    In: BMJ Open, BMJ, Vol. 9, No. 4 ( 2019-04), p. e026030-
    Abstract: Stage B heart failure (HF) is defined as an asymptomatic abnormality of the heart structure or function. The circulating level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) is elevated in symptomatic patients with left ventricular (LV) dysfunction caused by a structural or functional abnormality. This study investigated the association of the NT-proBNP level with echocardiography-detected cardiac structural or diastolic abnormalities in asymptomatic subjects with preserved LV systolic function (ejection fraction 〉 50%). Methods We retrospectively studied 652 health examinees who underwent echocardiography and an NT-proBNP test at a health-promotion centre in Seoul, between January 2016 and September 2018. The left ventricular mass index (LVMI) and the left atrial dimension (LAD) were used as markers for structural abnormalities, and the mean e’ velocity and mitral early flow velocity/early diastolic tissue velocity (E/e’) ratio were used as markers for diastolic dysfunction. The plasma NT-proBNP level was measured using electrochemiluminescence immunoassay (DPC Immulite 2000 XPi, Siemens Healthcare Diagnostics, Tarrytown, New York, USA). Results Subjects with preclinical structural abnormalities were older and had a higher body mass index (BMI), higher blood pressure, lower high-density lipoprotein cholesterol level, higher NT-proBNP level, and higher E/e’ (p 〈 0.05). Multivariate regression analysis indicated that the factors associated with a higher NT-proBNP level were older age, female sex, lower BMI, higher creatinine level, higher LVMI and higher LAD (p 〈 0.01). Conclusion Diastolic dysfunction is not associated with higher NT-proBNP levels, whereas preclinical cardiac structural abnormalities, as well as older age, female sex, lower BMI, and higher creatinine level, are associated with higher NT-proBNP levels.
    Type of Medium: Online Resource
    ISSN: 2044-6055 , 2044-6055
    URL: Article
    DOI: 10.1136/bmjopen-2018-026030
    Language: English
    Publisher: BMJ
    Publication Date: 2019
    detail.hit.zdb_id: 2599832-8
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