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  • 1
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    Online Resource
    Antibody response after two doses of homologous or heterologous SARS‐CoV‐2 vaccines in healthcare workers at health promotion centers: A prospective observational study
    Wiley ; 2022
    In:  Journal of Medical Virology Vol. 94, No. 10 ( 2022-10), p. 4719-4726
    Details
    In: Journal of Medical Virology, Wiley, Vol. 94, No. 10 ( 2022-10), p. 4719-4726
    Abstract: Assaying of anti‐spike‐protein receptor‐binding domain (S‐RBD) antibodies are used to aid evaluations of the immune statuses of individuals. The aim of this study was to determine the antibody response after two doses of homologous or heterologous severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines and to identify the factors affecting this response among healthcare workers (HCWs) at health promotion centers. In this prospective observational study, 1095 consenting HCWs were recruited from 16 health checkup centers and were tested at T0 (day of first dose), T1‐1 (1 month after first dose), T2‐0 (day of second dose), T2‐1 (1 month after second dose), and T2‐3 (3 months after second dose). SARS‐CoV‐2 antibodies were measured using a chemiluminescence microparticle immunoassay with SARS‐CoV‐2 IgG II Quant in the ARCHITECT system (Abbott Diagnostics). At T1‐1, anti‐SARS‐CoV‐2 S‐RBD IgG levels were significantly higher in participants who received messenger RNA (mRNA) vaccines than in those who received viral vector vaccines ( p  〈  0.001). At T2‐1, anti‐SARS‐CoV‐2 S‐RBD IgG levels were about 10 times higher than at T1‐1 in participants who received homologous mRNA vaccines, which decreased to a third of those at T2‐3. Anti‐SARS‐CoV‐2 S‐RBD IgG levels were highest among those who received homologous mRNA vaccines, followed by heterologous mRNA viral vector vaccines and homologous viral vector vaccines at T2‐3 ( p  〈  0.001). In a multivariable linear regression analysis, being female, taking at least one mRNA vaccine, and having a history of recovery from coronavirus disease 2019 (COVID‐19) were significantly associated with anti‐S‐RBD levels. Anti‐SARS‐CoV‐2 S‐RBD IgG levels were decreased at 3 months after two‐dose vaccinations and were associated with sex, vaccine type, and COVID‐19 history.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v94.10
    DOI: 10.1002/jmv.27911
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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  • 2
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    Prevalence of liver fibrosis and associated risk factors in the Korean general population: a retrospective cross-sectional study
    BMJ ; 2021
    In:  BMJ Open Vol. 11, No. 3 ( 2021-03), p. e046529-
    Details
    In: BMJ Open, BMJ, Vol. 11, No. 3 ( 2021-03), p. e046529-
    Abstract: The health burden of chronic liver disease is increasing worldwide. Its main histological consequence is liver fibrosis, and eventually cirrhosis. This process is rarely diagnosed at the pre-cirrhotic stage due to it being asymptomatic. Little is known about the prevalence of liver fibrosis and associated risk factors in the general population. The aims of this study were to determine the prevalence and distribution of liver fibrosis using magnetic resonance elastography (MRE), as well as the risk factors associated with liver fibrosis in the asymptomatic general population. Design, setting and participants This cross-sectional retrospective study consecutively selected subjects who underwent health check-ups including MRE at 13 health promotion centres in Korea between 2018 and 2020. Liver fibrosis was estimated using MRE with cut-off values for significant and advanced liver fibrosis of 2.90 and 3.60 kPa, respectively. Primary and secondary outcome measures The Χ 2 test was used to compare the prevalence of liver fibrosis according to sex and age groups. Multivariable logistic regression analyses were performed to identify the factors for significant and advanced liver fibrosis. Results Among the 8183 subjects, 778 (9.5%) had ≥significant fibrosis (≥2.9 kPa), which included 214 (2.6%) subjects with ≥advanced fibrosis (≥3.6 kPa). Multivariable analysis revealed that liver fibrosis was associated with age (OR=1.34, 95% CI=1.18 to 1.51), male sex (OR=3.18, 95% CI=1.97 to 5.13), diabetes (OR=2.43, 95% CI=1.8 to 3.28), HBsAg positivity (OR=3.49, 95% CI=2.55 to 4.79), abnormal liver function test (OR=1.9, 95% CI=1.49 to 2.42) and obesity (OR=1.77, 95% CI=1.35 to 2.32) (all p 〈 0.001), as well as metabolic syndrome (OR=1.4, 95% CI=1.05 to 1.87) (p=0.024). Conclusions The prevalence of significant or more liver fibrosis was high in the Korean general population and much higher among individuals with risk factors. This suggests that screening of liver fibrosis should be considered in general population, especially among high-risk groups.
    Type of Medium: Online Resource
    ISSN: 2044-6055 , 2044-6055
    URL: Article
    DOI: 10.1136/bmjopen-2020-046529
    Language: English
    Publisher: BMJ
    Publication Date: 2021
    detail.hit.zdb_id: 2599832-8
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  • 3
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    Chronic kidney disease in nonalcoholic fatty liver disease at primary healthcare centers in Korea
    Public Library of Science (PLoS) ; 2022
    In:  PLOS ONE Vol. 17, No. 12 ( 2022-12-20), p. e0279367-
    Details
    In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 12 ( 2022-12-20), p. e0279367-
    Abstract: The prevalence rates of nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are expected to increase with the rising trends in diabetes and obesity associated with aging populations. Considering the impacts of coexistent NAFLD and CKD on morbidity and mortality rates, screening strategies for groups at high-risk of CKD are needed in community-dwelling individuals with NAFLD. The aims of this study were to determine the prevalence and distribution of CKD in NAFLD, as well as the risk factors for CKD and the correlation with liver fibrosis in asymptomatic individuals with NAFLD at primary healthcare centers in Korea. Methods This retrospective cross-sectional study used data from 13 health-promotion centers in 10 Korean cities. Liver steatosis and stiffness were assessed using ultrasonography and magnetic resonance elastography (MRE), respectively. CKD was defined as an estimated glomerular filtration rate of 〈 60 mL/min/1.73m 2 , and urine albumin-to-creatinine ratio or proteinuria. CKD was categorized into four stages: no CKD, mild, moderate, and severe. Comparisons according to the CKD stages in NAFLD were performed using Student’s t -test or the chi-square test. Multivariable logistic regression analyses were performed to identify the risk factors for CKD and the correlation with liver fibrosis in NAFLD. Results The prevalence of CKD was 12.4% in NAFLD. Albuminuria (16.2%) and proteinuria (8.0%) were more prevalent in NAFLD. NAFLD (odd ratio = 1.27, 95% CI = 1.09–1.48, P = 0.003) was independently associated with CKD of at least mild stage. However, there was no significant association between CKD of at least moderate stage and NAFLD after adjusting for age and a metabolically unhealthy status. CKD was associated with significant liver fibrosis as measured by MRE in NAFLD. Conclusion The presence of NAFLD and liver fibrosis were independent risk factors for CKD, but NAFLD was not an independent risk factor for the later stages of CKD.
    Type of Medium: Online Resource
    ISSN: 1932-6203
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1371/journal.pone.0279367
    DOI: 10.1371/journal.pone.0279367.g001
    DOI: 10.1371/journal.pone.0279367.t001
    DOI: 10.1371/journal.pone.0279367.t002
    DOI: 10.1371/journal.pone.0279367.t003
    DOI: 10.1371/journal.pone.0279367.t004
    DOI: 10.1371/journal.pone.0279367.s001
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2022
    detail.hit.zdb_id: 2267670-3
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  • 4
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    Comparison of Urine Albumin-to-Creatinine Ratio (ACR) Between ACR Strip Test and Quantitative Test in Prediabetes and Diabetes
    Annals of Laboratory Medicine ; 2017
    In:  Annals of Laboratory Medicine Vol. 37, No. 1 ( 2017-01-01), p. 28-33
    Details
    In: Annals of Laboratory Medicine, Annals of Laboratory Medicine, Vol. 37, No. 1 ( 2017-01-01), p. 28-33
    Type of Medium: Online Resource
    ISSN: 2234-3806 , 2234-3814
    URL: Article
    DOI: 10.3343/alm.2017.37.1.28
    Language: English
    Publisher: Annals of Laboratory Medicine
    Publication Date: 2017
    detail.hit.zdb_id: 2677441-0
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  • 5
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    Human Papillomavirus Genotype Distribution Among 18,815 Women in 13 Korean Cities and Relationship With Cervical Cytology Findings
    Annals of Laboratory Medicine ; 2017
    In:  Annals of Laboratory Medicine Vol. 37, No. 5 ( 2017-09-01), p. 426-433
    Details
    In: Annals of Laboratory Medicine, Annals of Laboratory Medicine, Vol. 37, No. 5 ( 2017-09-01), p. 426-433
    Type of Medium: Online Resource
    ISSN: 2234-3806 , 2234-3814
    URL: Article
    DOI: 10.3343/alm.2017.37.5.426
    Language: English
    Publisher: Annals of Laboratory Medicine
    Publication Date: 2017
    detail.hit.zdb_id: 2677441-0
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  • 6
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    Distribution of hemoglobin levels and prevalence of anemia according to sex, age group, and region in 13 Korean cities
    Wiley ; 2020
    In:  International Journal of Laboratory Hematology Vol. 42, No. 2 ( 2020-04), p. 223-229
    Details
    In: International Journal of Laboratory Hematology, Wiley, Vol. 42, No. 2 ( 2020-04), p. 223-229
    Abstract: The distribution of hemoglobin (Hb) levels and the prevalence of anemia are significant public health indicators. The aims of this study were to determine the distribution of Hb levels and the prevalence of anemia according to sex, age group, and region throughout Korea. Methods The study analyzed data on 1 159 298 subjects who received health checkups at 16 health‐promotion centers in 13 Korean cities during 2018. Anemia and its severity were defined according to the World Health Organization classification for Hb levels as follows: mild anemia (11‐12.9 g/dL in males and 11‐11.9 g/dL in females), moderate anemia (10‐10.9 g/dL in both sexes), and severe anemia ( 〈 10.0 g/dL in both sexes). Results The Hb level in the general sample was lower in females (13.25 ± 1.13 g/dL, mean ± SD) than in males (15.29 ± 1.22 g/dL). The overall prevalence of anemia was 6.0% (2.98% in males and 8.56% in females), and the prevalence of severe anemia was 0.92% (0.23% in males and 1.51% in females). While the prevalence of anemia increased monotonically with age in males, it was bimodal in females with two peaks at 40‐49 years and ≥80 years. The highest prevalence of anemia in females aged 40‐49 years was attributed to microcytic anemia, while increases in anemia prevalence in males aged ≥50 years and females aged ≥70 years were attributed to macrocytic anemia. Conclusion The distribution of Hb levels and the prevalence of anemia overall and by severity differ according to sex, age group, and region throughout Korea.
    Type of Medium: Online Resource
    ISSN: 1751-5521 , 1751-553X
    URL: Issue
    URL: Article
    DOI: 10.1111/ijlh.v42.2
    DOI: 10.1111/ijlh.13160
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2268600-9
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  • 7
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    ApoE4 genotype and cognitive performance in Korean health examinees with subjective memory complaints: A retrospective cross-sectional study
    Open Access Text Pvt, Ltd. ; 2020
    In:  Journal of Translational Science Vol. 6, No. 3 ( 2020)
    Details
    In: Journal of Translational Science, Open Access Text Pvt, Ltd., Vol. 6, No. 3 ( 2020)
    Type of Medium: Online Resource
    ISSN: 2059-268X
    URL: Journal
    URL: Article
    DOI: 10.15761/JTS
    DOI: 10.15761/JTS.1000339
    Language: Unknown
    Publisher: Open Access Text Pvt, Ltd.
    Publication Date: 2020
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  • 8
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    Reference interval and the role of soluble suppression of tumorigenicity 2 (sST2) in subclinical cardiac dysfunction at health checkups
    Wiley ; 2020
    In:  Journal of Clinical Laboratory Analysis Vol. 34, No. 11 ( 2020-11)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 34, No. 11 ( 2020-11)
    Abstract: Soluble ST2 (sST2) is known to predict adverse outcomes and death in individuals with established heart failure. However, the role of sST2 testing in the general population has not been established. The aims of this study were to determine the reference interval (RI) and the clinical utility of sST2 in subclinical cardiac dysfunction in general population. Methods This cross‐sectional study consecutively selected 41,806 general subjects at health checkups who underwent echocardiography and sST2 testing at 16 health promotion centers in 13 Korean cities. The reference subjects were obtained among those with normal findings in echocardiography. Sex‐specific RIs were established according to the CLSI C28‐A3 guidelines. sST2 was measured using immunoassay with the Presage ST2 assay (Critical Diagnostics). Results In the general subjects, age, sex, BMI, systolic blood pressure, blood glucose, creatinine, liver function, and triglycerides were associated with the sST2 levels. The RI for sST2 was higher in males (≤49.6 ng/mL, 95% CI = 48.5‐51.5) than in females (≤44.5 ng/mL, 95% CI = 43.5‐45.6) and higher in subjects aged  〈  40 years than ≥ 40 years in both sexes. The sST2 levels were 29.1 ± 10.7 (mean ± SD) and 29.1 ± 14.4 ng/mL in the groups with normal cardiac function and subclinical cardiac dysfunction, respectively. The sST2 level was not associated with subclinical cardiac dysfunction (odd ratio = 1.002, P  = .13). Conclusions RIs obtained from a large and echocardiography‐proven healthy community‐based sample are presented. Subclinical cardiac dysfunction was associated with older age, male sex, and metabolic factors but not with the sST2 level.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v34.11
    DOI: 10.1002/jcla.23461
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2001635-9
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  • 9
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    Establishment and validation of reference intervals for tumor markers (AFP, CEA, CA19‐9, CA15‐3, CA125, PSA, HE4, Cyfra 21‐1, and ProGRP) in primary care centers in Korea: A cross‐sectional retrospective study
    Wiley ; 2023
    In:  Health Science Reports Vol. 6, No. 2 ( 2023-02)
    Details
    In: Health Science Reports, Wiley, Vol. 6, No. 2 ( 2023-02)
    Abstract: The reference interval (RI) for a tumor marker may vary between populations, detection systems, and the methods used to obtain their values. The aims of this study were to establish age‐ and sex‐specific RIs for the following nine common tumor markers and to validate the established RIs in Korean adults: alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), cancer antigen (CA) 19‐9, CA15‐3, CA125, Human epididymis protein 4 (HE4), total prostate specific antigen, cytokeratin fragment (Cyfra) 21‐1, and progastrin‐releasing peptide (ProGRP). Methods This cross‐sectional study consecutively selected 214,159 individuals (aged 18–98 years) who underwent health checkups at 16 health‐promotion centers in 13 Korean cities. Finally, 62,752 examinees were used to establish the RIs after removing outliers. RIs were established using an indirect method according to the CLSI EP28‐A3C guideline. The established RIs were validated by calculating the proportion of individuals outside each RI. Results Sex‐related differences were observed for AFP, CEA, CA19‐9, Cyfra 21‐1, and ProGRP ( p   〈  0.05): AFP, CEA and Cyfra 21‐1 were higher in males, and CA19‐9 and proGRP were higher in females. Most of the tumor markers except CA15‐3 and CA125 increased with age: CA125 decreased at ≥50 years of age ( p   〈  0.05), while CA15‐3 did not vary with age. Less than 5% of subjects were outside all RIs (the 2.5th and 97.5th percentiles) established in the present study. Meanwhile, less than 3% of the healthy reference subjects fell outside the current and manufacturers' RIs of all tumor markers except Cyfra 21‐1. Conclusion This study has determined age‐ and sex‐specific RIs for nine common tumor markers in the healthy Korean population, which could be useful for clinicians making clinical decisions and assessments.
    Type of Medium: Online Resource
    ISSN: 2398-8835 , 2398-8835
    URL: Issue
    URL: Article
    DOI: 10.1002/hsr2.v6.2
    DOI: 10.1002/hsr2.1107
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2927182-4
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  • 10
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    Evaluation of the LC-1000 Flow Cytometry Screening System for Cervical Cancer Screening in Routine Health Checkups
    S. Karger AG ; 2018
    In:  Acta Cytologica Vol. 62, No. 4 ( 2018), p. 279-287
    Details
    In: Acta Cytologica, S. Karger AG, Vol. 62, No. 4 ( 2018), p. 279-287
    Abstract: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 This study evaluated the performance of a flow cytometry system (LC-1000) in screening cervical precancerous lesions at routine health checkups. 〈 b 〉 〈 i 〉 Study design: 〈 /i 〉 〈 /b 〉 In total, 928 health examinees were enrolled at 16 health promotion centers in 13 Korean cities between 2016 and 2017. All participants underwent liquid-based cervical cytology and flow cytometry testing to determine the cell proliferation index (CPIx). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The positivity rate of the LC-1000 system increased with the severity of the cervical cytology findings ( 〈 i 〉 p 〈 /i 〉 for trend & #x3c; 0.001). When low-grade squamous intraepithelial lesion (LSIL) or higher (including LSIL, high-grade squamous intraepithelial lesion [HSIL], and atypical squamous cells without excluding HSIL [ASC-H] ) was defined as gold-standard positivity, the sensitivity, specificity, PPV, and NPV of LC-1000 were 75.3% (95% confidence interval [CI], 66.8–83.7), 58.5% (95% CI, 55.2–61.9), 18.1% (95% CI, 14.5–21.8), and 95.1% [95% CI, 93.2–97.0] , respectively. The median CPIx increased significantly from normal cytology to HSIL ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). The median CPIx was higher in high-risk human papillomavirus (HR-HPV)-positive cases than in HR-HPV-negative cases (0.23 vs. 0.17, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), while it did not differ between HR-HPV-positive and HR-HPV-negative cases with normal cytology findings (0.16 vs. 0.16, 〈 i 〉 p 〈 /i 〉 = 0.700). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The LC-1000 system is potentially useful for screening cervical precancer and cancer, especially when excluding normal or ASC of undetermined significance cases in routinely screened populations.
    Type of Medium: Online Resource
    ISSN: 0001-5547 , 1938-2650
    URL: Article
    DOI: 10.1159/000489079
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 2256676-4
    SSG: 12
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