In:
The Korean Journal of Helicobacter and Upper Gastrointestinal Research, Korean College of Helicobacter and Upper Gastrointestinal Research, Vol. 21, No. 1 ( 2021-03-10), p. 48-58
Abstract:
Background/Aims: The eradication rate of the first-line standard triple therapy (STT) for 〈 i 〉 Helicobacter pylori 〈 /i 〉 ( 〈 i 〉 H. pylori 〈 /i 〉 ) infection has decreased since 2000; therefore, other first-line therapies are required. This study was aimed at investigating the efficacy of bismuth-containing quadruple therapy (PBMT) for first-line 〈 i 〉 H. pylori 〈 /i 〉 eradication compared to STT, sequential therapy (SQT), and concomitant therapy (CT).Materials and Methods: The Ovid-MEDLINE, Koreamed, EMBASE, KMBASE, and Cochrane Library databases were searched from January 2008 to July 2018. All identified randomized controlled trials (RCTs) comparing PBMT and non-PBMT for first-line 〈 i 〉 H. pylori 〈 /i 〉 eradication therapy were included in the final analysis.Results: A total of 3,653 patients from seven RCTs were enrolled. The pooled eradication rates of PBMT by intention-to-treat (ITT) and per-protocol (PP) analyses were 82.1% (95% CI, 68.2~90.8%) and 88.8% (95% CI, 77.1~94.9%), respectively. However, no statistically significant difference was observed in eradication rates of the 10- or 14-day PBMT as compared to 14-day STT, 10-day SQT, and 10-day CT in ITT and PP analyses. PBMT was significantly higher in adverse events than in the other eradication regimens (RR, 1.64; 95% CI, 1.11~2.44). Considerable heterogeneity in adverse events was observed among studies (χ 〈 sup 〉 2 〈 /sup 〉 =88.7; 〈 i 〉 P 〈 /i 〉 〈 0.001, I 〈 sup 〉 2 〈 /sup 〉 =93%).Conclusions: PBMT can be the first-line treatment for 〈 i 〉 H. pylori 〈 /i 〉 eradication in Korea when other first-line options, including STT, SQT, or CT, are unavailable due to their high adverse event rates.
Type of Medium:
Online Resource
ISSN:
1738-3331
,
2671-826X
DOI:
10.7704/kjhugr.2020.0052
Language:
English
Publisher:
Korean College of Helicobacter and Upper Gastrointestinal Research
Publication Date:
2021
detail.hit.zdb_id:
3071420-5
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