In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 11 ( 2021-11-22), p. e0260309-
Abstract:
Liver cirrhosis and features of muscle or adipose tissues may affect the severity of acute pancreatitis (AP). We aimed to evaluate the impact of body composition parameters and liver cirrhosis on the severity of AP in patients with alcohol-induced AP (AAP). Methods Patients with presumed AAP who underwent CT within one week after admission were retrospectively enrolled. L3 sectional areas of abdominal fat and muscle, and mean muscle attenuations (MMAs) were quantified. The presence of liver cirrhosis was determined using clinical and CT findings. Factors potentially associated with moderately severe or severe AP were included in the multivariable logistic regression analysis. Results A total of 242 patients (47.0 ± 12.6 years, 215 males) with presumed AAP were included. The mild and moderately severe/severe (MSS) groups included 137 (56.6%) and 105 patients (43.4%), respectively. Patients in the MSS group had higher rates of liver cirrhosis, organ failure, and local complications. Among body composition parameters, mean MMA (33.4 vs 36.8 HU, P 〈 0.0001) and abdominal muscle mass (126.5 vs 135.1 cm 2 , P = 0.029) were significantly lower in the MSS group. The presence of liver cirrhosis (OR, 4.192; 95% CI, 1.620–10.848) was found to be a significant risk factor for moderately severe or severe AP by multivariable analysis. Conclusion The results of this study suggest that liver cirrhosis has a significant impact on the severity of AAP. Of the body composition parameters examined, MMA and abdominal muscle mass showed potential as promising predictors.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0260309
DOI:
10.1371/journal.pone.0260309.g001
DOI:
10.1371/journal.pone.0260309.g002
DOI:
10.1371/journal.pone.0260309.t001
DOI:
10.1371/journal.pone.0260309.t002
DOI:
10.1371/journal.pone.0260309.t003
DOI:
10.1371/journal.pone.0260309.t004
DOI:
10.1371/journal.pone.0260309.s001
DOI:
10.1371/journal.pone.0260309.s002
DOI:
10.1371/journal.pone.0260309.r001
DOI:
10.1371/journal.pone.0260309.r002
DOI:
10.1371/journal.pone.0260309.r003
DOI:
10.1371/journal.pone.0260309.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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