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  • 1
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    Effect of body mass index on peak growth hormone level after growth hormone stimulation test in children with short stature
    Korean Society of Pediatric Endocrinology ; 2021
    In:  Annals of Pediatric Endocrinology & Metabolism Vol. 26, No. 3 ( 2021-09-30), p. 192-198
    Details
    In: Annals of Pediatric Endocrinology & Metabolism, Korean Society of Pediatric Endocrinology, Vol. 26, No. 3 ( 2021-09-30), p. 192-198
    Abstract: Purpose: The aim of this study is to evaluate the effect of body mass index (BMI) on peak serum growth hormone (GH) level after GH stimulation test in children with short stature.Methods: Data were obtained from retrospective medical record reviews of those who visited the pediatric endocrine clinic at St. Vincent’s Hospital of Catholic University for short stature from January 2010 to June 2019. A total of 115 children (66 boys and 49 girls) whose height was less than the third percentile according to age and sex underwent GH stimulation testing.Results: Of the 115 subjects, 47 were diagnosed with GH deficiency (GHD) and 68 were diagnosed with idiopathic short stature (ISS). In patients with GHD, weight standard deviation score (SDS) (P 〈 0.001) and BMI SDS (P≤0.001) were higher, and free thyroxine (T4) level (P=0.012) was lower than those in the ISS group. In total subjects, peak serum GH level after GH stimulation test showed negative correlations with weight SDS (r=-0.465, P 〈 0.001), BMI SDS (r=-0.398, P 〈 0.001), and thyroid stimulating hormone (r=-0.248, P=0.008) and a positive correlation with free T4 (r=0.326, P 〈 0.001). In multiple regression analysis, BMI SDS (P=0.003) was negatively associated with peak serum GH level in GH stimulation testing after adjusting for age, sex, pubertal status, and type of pharmacological stimulus.Conclusion: The BMI SDS influences peak serum GH level after GH stimulation testing. We should consider BMI factors when interpreting the results of GH stimulation testing.
    Type of Medium: Online Resource
    ISSN: 2287-1012 , 2287-1292
    URL: Article
    DOI: 10.6065/apem.2040246.123
    Language: English
    Publisher: Korean Society of Pediatric Endocrinology
    Publication Date: 2021
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  • 2
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    MON-243 The Difference of Body Mass Index Score before and after Gonadotropin-Releasing Hormone Agonist Treatment in Cerntral Precocious Puberty Girls
    The Endocrine Society ; 2019
    In:  Journal of the Endocrine Society Vol. 3, No. Supplement_1 ( 2019-04-15)
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 3, No. Supplement_1 ( 2019-04-15)
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/js.2019-MON-243
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2019
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  • 3
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    SAT-249 Comparison of Different Criteria for the Definition of Insulin Resistance and Its Relation with Metabolic Risk in Overweight and Obese Adolescents
    The Endocrine Society ; 2019
    In:  Journal of the Endocrine Society Vol. 3, No. Supplement_1 ( 2019-04-15)
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 3, No. Supplement_1 ( 2019-04-15)
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/js.2019-SAT-249
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2019
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  • 4
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    SUN-261 Growth Patterns over Two Years after Birth According to the Birth Weight and Length Percentile in Children Born Preterm
    The Endocrine Society ; 2019
    In:  Journal of the Endocrine Society Vol. 3, No. Supplement_1 ( 2019-04-15)
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 3, No. Supplement_1 ( 2019-04-15)
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/js.2019-SUN-261
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2019
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  • 5
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    SAT-070 Nutritional Deficiency of Calcium Mimicking P Seudohypoparathyroidism
    The Endocrine Society ; 2020
    In:  Journal of the Endocrine Society Vol. 4, No. Supplement_1 ( 2020-05-08)
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 4, No. Supplement_1 ( 2020-05-08)
    Abstract: BACKGROUND: Childhood hypocalcemia in general is caused by problems associated with calcium absorption and excretion, parathyroid hormone (PTH) secretion, and vitamin D metabolism. Clinical manifestations can vary from asymptomatic hypocalcemia to life-threatening conditions including convulsions, tetany and laryngeal spasm. As many symptoms are nonspecific, laboratory tests are essential for diagnosis. Nevertheless, the causes of hypocalcemia may not be determined by simple interpretation of baseline calcium, phosphorus, alkaline phosphatase (ALP), PTH and calcidiol (25OHD). Case presentation: We report a case of 11-month-old female with a generalized tonic type seizure with low serum calcium level (5.7 mg/dl), 25OHD (23.2 ng/mL) and calcitriol (1,25OH2D) (12.83 pg/mL). Serum phosphorus (5.9 mg/dL), ALP (209 mg/dL) were above normal range and PTH (484 pg/mL) was markedly elevated. She had a problem with weaning process after age of 5 months and milk powder was her main staple diet. Pseudohypoparathyroidism (PHP) was suspected due to slightly increased serum phosphorus, however Albright’s hereditary osteodystrophy manifestation was absent and no GNAS methylation defect was identified. Serum calcium was normalized by intravenous calcium-gluconate followed by oral calcium carbonate and vitamin D supplement. Two months of oral oral calcium carbonate and vitamin D supplementation alone normalized all laboratory results. Conclusions: Severe nutritional deficiency of calcium could mimic laboratory findings of PHP, therefore clinical judgement should not be made solely on biochemical markers. Keywords: Hypocalcemia, pseudohypoparathyroidism, rickets 제1저자: Yoonji Lee, Moonbae Ahn, Na yeong Lee, Seonhwa Lee, Yujung Choi, Seulki Kim, Shinhee Kim, Wonkyoung Cho, Kyoungsoon Cho, Minho Jung, and Byungkyu Suh* Department of Pediatrics, College of Medicine, Catholic University of Korea
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvaa046.474
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2020
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  • 6
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    Factors Affecting Thyroid Hormone Changes Over 1 Month After Birth in Preterm Newborns
    The Endocrine Society ; 2021
    In:  Journal of the Endocrine Society Vol. 5, No. Supplement_1 ( 2021-05-03), p. A714-A714
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 5, No. Supplement_1 ( 2021-05-03), p. A714-A714
    Abstract: Purpose: To analyze factors affecting thyroid hormone changes over 1 month after birth in preterm newborns. Methods: Thyroid hormones, including free thyroxine (fT4) and thyroid stimulating hormone (TSH) of 216 preterm newborns (mean gestational age [GA] 33.6±2.6 weeks), were retrospectively reviewed at the 1st and 4th weeks after birth. Preterm newborns were classified into three groups according to the GA ( & lt; 28 weeks, group A; 28-32 weeks, group B; 32-36 weeks, group C). The association between thyroid hormone changes and clinical factors was analyzed. Results: Preterm newborns with older GA had higher concentrations of fT4 (group A, 0.9±0.2 ng/dL; group B, 1.2±0.2 ng/dL; group C, 1.5±0.3 ng/dL) and TSH (group A, 2.7±3.2 mIU/L; group B, 4.5±3.3 mIU/L; group C, 6.0±3.8 mIU/L), both at the 1st week after birth. fT4 and TSH at the 1st week after birth were positively correlated with the GA (r=0.52, P=0.0001; r=0.30, P=0.0001) and Apgar score at 5 minutes (r=0.31, P=0.0001; r=0.28, P=0.0001). TSH concentration at the 1st week after birth was significantly lower in the abnormal brain sonogram group than in the normal brain sonogram group (4.4±3.7 vs 6.1±3.4 mIU/L, P=0.001); there were no differences at the 4th week after birth between these groups (4.2±2.6 vs 3.4±2.4 mIU/L, P=0.485). Multiple linear regression analysis revealed that GA was positively correlated with fT4 and TSH at the 1st week, and fT4 at 4th week after birth (B=0.08, SE=0.12, P=0.0001; B=0.34, SE=0.15, P=0.029; B=0.02, SE=0.01, P=0.013). Conclusion: Thyroid hormone levels in preterm newborns are mostly within the normal reference value of full-term newborns within 4 weeks of life, and are mainly affected by GA and brain ultrasound abnormalities.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvab048.1453
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2021
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  • 7
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    Growth patterns over 2 years after birth according to birth weight and length percentiles in children born preterm
    Korean Society of Pediatric Endocrinology ; 2020
    In:  Annals of Pediatric Endocrinology & Metabolism Vol. 25, No. 3 ( 2020-09-30), p. 163-168
    Details
    In: Annals of Pediatric Endocrinology & Metabolism, Korean Society of Pediatric Endocrinology, Vol. 25, No. 3 ( 2020-09-30), p. 163-168
    Type of Medium: Online Resource
    ISSN: 2287-1012 , 2287-1292
    URL: Article
    DOI: 10.6065/apem.1938180.090
    Language: English
    Publisher: Korean Society of Pediatric Endocrinology
    Publication Date: 2020
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  • 8
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    THU138 The Association Between Irisin And Anthropometric And Metabolic Parameters In Obese Children And Adolescents
    The Endocrine Society ; 2023
    In:  Journal of the Endocrine Society Vol. 7, No. Supplement_1 ( 2023-10-05)
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 7, No. Supplement_1 ( 2023-10-05)
    Abstract: Disclosure: S. Kim: None. S. Kim: None. S. Park: None. S. Sim: None. S. Kim: None. M. Ahn: None. C. Won-kyoung: None. C. Kyoung Soon: None. M. Jung: None. B. Suh: None. Background: Irisin is a myokine secreted from skeletal muscle that plays an important role in the regulation of adipokine secretion and the differentiation of osteoblast and osteoclasts. Irisin has been shown to increase browning of adipose tissue, thermogenesis, energy expenditure, and insulin sensitivity. The aim of this study was to evaluate the relation of serum irisin level with metabolic, anthropometric parameters and bone mineral density in children and adolescents. Methods: This study included 103 Korean children and adolescents in a single center: 49 (47.6 %) obese participants with a body mass index (BMI) ≥95th percentile and 54 (52.4%) healthy control with BMI 15-85th percentile. Fasting serum irisin was quantitatively assayed by ELISA. Lipid profile, fasting blood glucose, fasting insulin, the homeostasis model assessment of insulin resistance (HOMA-IR), Tryglyceride and glucose (TyG) index, osteocalcin and 25-hydroxyvitamin D3 were measured as metabolic parameters. Bone mineral density (BMD) was performed by dual energy X-ray absorptiometry (DXA) in 33 healthy subjects. Results: Serum irsin was significantly higher in obese group than in control group (mean 18.1 ± 3.5 vs 16.2 ± 2.0ng/mL; P = 0.002). There was no significant difference in serum irisin levels between prepubertal and pubertal subjects. In the all participants, irisin level was positively correlated with height SDS (r = 0.24; P = 0.02), BMI SDS (r = 0.37; P & lt;0.001), HOMA-IR(r = 0.21; P = 0.04) and osteocalcin (r = 0.27; P = 0.006). Serum irisin level was negatively correlated with HDL cholesterol (r = -0.29; P = 0.005) and positively correlated with total body less head (TBLH) Z-score (r = 0.40, P = 0.03). Conclusions: This study showed the association between irisin levels with BMI standard deviation score, HOMA-IR and HDL cholesterol. Our data showed a positive correlation between irisin levels and BMD in healthy subjects. Further studies are needed to clarify the mechanisms by which irisin could affect glucose/lipid metabolism and bone metabolism. Presentation: Thursday, June 15, 2023
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvad114.1390
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2023
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  • 9
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    Goiter at Diagnosis Might Be Predicting Factor for Early Onset Intractable Graves’ Disease
    The Endocrine Society ; 2021
    In:  Journal of the Endocrine Society Vol. 5, No. Supplement_1 ( 2021-05-03), p. A830-A830
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 5, No. Supplement_1 ( 2021-05-03), p. A830-A830
    Abstract: Introduction: The clinical course of Graves’ disease (GD) treated with anti-thyroid drug (ATD) treatment were reviewed with the aim of establishing criteria able to predict intractable GD. Methods: The clinical course of 116 patients with GD who agreed to participate in this study between March 2009 and August 2019 in the pediatric endocrine clinic at Seoul St. Mary’s and St. Vincent’s Hospitals were reviewed. We defined an intractable as hyperthyroidism persistent over 2 years of ATD or relapsed after ATD withdrawal or had been treated ATD for at least 5 years [1-3]. Result: Of 116 patients diagnosed with GD, 37 patients (31.8%) had remission and 79 (68.2%) had intractable GD. Between intractable and remission GD group, there were no significant difference of female percentage, age at diagnosis, thyroid associated ophthalmopathy, serum levels of triiodothyronine (T3), free tetraiodothyronine (T4), Thyroid stimulating hormone (TSH) and positive rate of thyroid autoantibody (Thyroid peroxidase (TPO), Thyroglobulin (Tg), Thyroid stimulating hormone receptor (TSHR)). In intractable GD patients, the frequency of goiter at diagnosis is higher than remission group (89.9% [71/79] and 70.3% [26/37], P-value = 0.014). In correlation analysis, intractable GD showed positive correlation with goiter (R=0.247, P-value = 0.008). In multivariate logistic analyses, goiter is showed strong relationship with intractable GD (odds ratio, 3.793; 95% confidence interval, 1.367-10.524) after adjusting age and sex. Conclusion: Our study supported that goiter at initial presentation might be predicting factor for early onset intractable GD.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvab048.1692
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2021
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  • 10
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    The Effects of Conditioning Regimen on Thyroid Function After Hematopoietic Stem Cell Transplantation in Children: 2-Year Short Term Follow Up
    The Endocrine Society ; 2021
    In:  Journal of the Endocrine Society Vol. 5, No. Supplement_1 ( 2021-05-03), p. A721-A722
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 5, No. Supplement_1 ( 2021-05-03), p. A721-A722
    Abstract: Background: Long term effect of conditioning regimen such as Total body irradiation (TBI) and chemotherapy has been studied. However short term effect of conditioning regimen on endocrinologic system was not well known. Purpose. Our study aimed to evaluate the effect of conditioning regimen on thyroid function in children who had HSCT after 2 years. Methods:. Date was obtained from retrospective review of medical records who treated malignant hematologic disease and transplanted hematopoietic stem cell in Seoul St. Mary’s hospital from January 1, 2010 to August 31, 2018. Among 563 patients who underwent HSCT for about 9 years, we studied 150 patients who conforming to inclusion criteria of this study. Thyroid function was tested before HSCT and follow 12 and 24 months. Anthropometric date, duration of chemotherapy, history of relapse, graft versus host disease (GVHD) were also analyzed. Results: In patient’s characteristics, median age at HSCT was 10.49 (0.89 - 19.29) years. Out of 150 patients, male was 92 and female was 58. Acute lymphoid leukemia (ALL) was 74, acute myeloid leukemia (AML) was 76. Among them, busulfan based conditioning was done in 53 patients, TBI based conditioning regimen used in 72 and 25 patients had done TBI with busulfan based conditioning regimen. Fifteen patients (12.5%) had thyroid dysfunction after 2 years of HSCT (4 euthyroid sick syndrome, 11 subclinical hypothyroidism and 1 high T4 syndrome). Incidence of thyroid dysfunction by conditioning regimen was different at 2 years after HSCT, higher in TBI with busulfan based group (p = 0.033). In univariate regression analysis, using conditioning regimen, by TBI with busulfan was risk factor of thyroid dysfunction at 2 years after HSCT. Conclusions: TBI with busulfan based group showed higher incidence of thyroid dysfunction and conditioning regimen was risk factor of thyroid dysfunction at 2 years after HSCT.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvab048.1469
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2021
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