In:
Journal of Bioactive and Compatible Polymers, SAGE Publications, Vol. 28, No. 3 ( 2013-05), p. 233-246
Abstract:
Synthetic vessel grafts have been used as vascular substitutes for cardiovascular bypass procedures. In this study, we developed a novel tubular double-layered poly(l-lactide-co-ϵ-caprolactone) scaffold that did not require pretreatment with cell seeding by promoting autologous tissue regeneration by inducing the proliferation and differentiation of endothelial and smooth muscle progenitor cells after implantation. The patency and mechanical properties were maintained for one year after implantation, although 95% of the poly(l-lactide-co-ϵ-caprolactone) scaffolds had degraded. After this period, there was a lining of endothelial cells, an accumulation of collagen and elastin, and the development of neovascularization inside the poly(l-lactide-co-ϵ-caprolactone).
Type of Medium:
Online Resource
ISSN:
0883-9115
,
1530-8030
DOI:
10.1177/0883911513477750
Language:
English
Publisher:
SAGE Publications
Publication Date:
2013
detail.hit.zdb_id:
2073790-7
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