In:
Journal of the International AIDS Society, Wiley, Vol. 17, No. 1 ( 2014-01)
Abstract:
Low bone mass is prevalent in HIV‐positive patients. However, compared to Western countries, less is known about HIV‐associated osteopenia in Asian populations. Methods We performed a cross‐sectional survey in Seoul National University Hospital from December 2011 to May 2012. We measured bone mineral density using central dual energy X‐ray absorptiometry, with consent, in male HIV‐positive patients, aged 40 years and older. Diagnosis of low bone mass was made using International Society for Clinical Densitometry Z‐score criteria in the 40–49 years age group and World Health Organization T‐score criteria in the 〉 50‐year age group. The data were compared with those of a community‐based cohort in Korea. Results Eighty‐four HIV‐positive male patients were included in this study. Median age was 49 (interquartile range [IQR], 45–56) years, and median body mass index (BMI) was 22.6 (IQR, 20.9–24.4). Viral suppression was achieved in 75 (89.3%) patients and median duration of antiretroviral therapy was 71 (IQR, 36–120) months. The overall prevalence of low bone mass was 16.7% in the 40–49 years age group and 54.8% in the 〉 50 years age group. Our cohort had significantly lower bone mass at the femur neck and total hip than HIV‐negative Koreans in the 40–49 years age group. Low bone mass was significantly associated with low BMI, and a high level of serum carboxy‐terminal collagen crosslinks, but was not associated with antiretroviral regimen or duration of antiretroviral therapy. Conclusions Low bone mass is prevalent in Korean HIV‐positive males undergoing antiretroviral therapy, and may be associated with increased bone resorption.
Type of Medium:
Online Resource
ISSN:
1758-2652
,
1758-2652
DOI:
10.7448/IAS.17.1.18773
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2467110-1
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