In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 2 ( 2021-2-5), p. e0245052-
Abstract:
Emerging evidence that an elevated serum gamma-glutamyltransferase (GGT) level is associated with an increased risk of gastrointestinal cancer, but still controversial. The aim of this study to assess the relationship between GGT level and risk of gastrointestinal cancer, and the contribution of the interaction of hyperglycemia with elevated GGT level to the incidence of gastrointestinal cancer by the stratified analysis. A total of 8,120,665 Koreans who received medical checkups in 2009 were included. Subjects were classified according to the quartile of GGT level for women and men. The incidence rates of gastrointestinal cancer for each group were analyzed using Cox proportional hazards models. During follow-up, 129,853 cases of gastrointestinal cancer newly occurred (esophagus, 3,792; stomach, 57,932; and colorectal, 68,789 cases). The highest GGT quartile group showed an increased risk of gastrointestinal cancer (esophagus, hazard ratio = 2.408 [95% confidence interval, 2.184–2.654]; stomach, 1.121 [1.093–1.149] ; and colorectal, 1.185 [1.158–1.211]). The risk increased significantly with the rise in GGT quartile level, regardless of the site of cancer. The stratified analysis according to glycemic status showed that the effect of elevated GGT was predominant in the risk of esophageal cancer. The effect of elevated GGT further increased the risk of stomach and colorectal cancers in diabetic patients. An elevated level of GGT was associated with an increased risk of gastrointestinal cancer, regardless of the site of cancer. The effect of the increase in GGT level on the risk of gastrointestinal cancer depended on the type of cancer and glycemic status.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0245052
DOI:
10.1371/journal.pone.0245052.g001
DOI:
10.1371/journal.pone.0245052.g002
DOI:
10.1371/journal.pone.0245052.g003
DOI:
10.1371/journal.pone.0245052.t001
DOI:
10.1371/journal.pone.0245052.t002
DOI:
10.1371/journal.pone.0245052.t003
DOI:
10.1371/journal.pone.0245052.t004
DOI:
10.1371/journal.pone.0245052.s001
DOI:
10.1371/journal.pone.0245052.s002
DOI:
10.1371/journal.pone.0245052.s003
DOI:
10.1371/journal.pone.0245052.s004
DOI:
10.1371/journal.pone.0245052.s005
DOI:
10.1371/journal.pone.0245052.r001
DOI:
10.1371/journal.pone.0245052.r002
DOI:
10.1371/journal.pone.0245052.r003
DOI:
10.1371/journal.pone.0245052.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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