In:
Clinical and Translational Gastroenterology, Ovid Technologies (Wolters Kluwer Health), Vol. 11, No. 4 ( 2020-4-2), p. e00157-
Abstract:
Because nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of chronic liver disease, noninvasive evaluations of its severity are immediately needed. This prospective cross-sectional study evaluated the effectiveness of noninvasive assessments of hepatic steatosis, fibrosis, and steatohepatitis. METHODS: Patients underwent laboratory tests, liver biopsy, transient elastography, and MRI. Multiparametric MR was used to measure MRI proton density fat fraction, MR spectroscopy, T1 mapping, and MR elastography (MRE). RESULTS: We enrolled 130 patients between October 2016 and July 2019. For the diagnosis of moderate-to-severe steatosis (grade ≥ 2), the area under the receiver operating characteristic curve (AUROC) was lower in controlled attenuation parameter (0.69; 95% confidence interval [CI], 0.60–0.76) than MRI proton density fat fraction (0.82; 95% CI, 0.75–0.89; P = 0.008) and MR spectroscopy (0.83; 95% CI, 0.75–0.89; P = 0.006). For the diagnosis of advanced fibrosis (stage ≥ 3), the AUROC of MRE (0.89; 95% CI, 0.83–0.94) was superior compared with those of the Fibrosis-4 index (0.77; 95% CI, 0.69–0.84; P = 0.010), NAFLD fibrosis score (0.81; 95% CI, 0.73–0.87; P = 0.043), and transient elastography (0.82; 95% CI, 0.74–0.88; P = 0.062). For detecting advanced fibrosis or nonalcoholic steatohepatitis, the AUROC of MRE (0.86; 95% CI, 0.79–0.91) was higher than that of TE (0.76; 95% CI, 0.68–0.83) with statistical significance ( P = 0.018). DISCUSSION: Multiparametric MR accurately identified a severe form of NAFLD. Multiparametric MR can be a valuable noninvasive method for evaluating the severity of NAFLD.
Type of Medium:
Online Resource
ISSN:
2155-384X
DOI:
10.14309/ctg.0000000000000157
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2020
detail.hit.zdb_id:
2581516-7
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