GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • MDPI AG  (28)
  • Kim, Jae-Hoon  (28)
  • 1
    Online Resource
    Online Resource
    Nectin-4 as a Predictive Marker for Poor Prognosis of Endometrial Cancer with Mismatch Repair Impairment
    MDPI AG ; 2023
    In:  Cancers Vol. 15, No. 10 ( 2023-05-22), p. 2865-
    Details
    In: Cancers, MDPI AG, Vol. 15, No. 10 ( 2023-05-22), p. 2865-
    Abstract: The adhesion molecule Nectin-4 is a new potential therapeutic target for different types of cancer; however, little is known about its diagnosis significance in endometrial cancer (EC). We found that Nectin-4 expression was significantly higher in EC tissues than in nonadjacent normal tissue. The area under the receiver operating characteristic curve value of 0.922 indicated good diagnostic accuracy for Nectin-4 expression in EC. Furthermore, Nectin-4 expression was associated with DNA mismatch repair (MMR) protein deficiency. Notably, the high Nectin-4 expression group of patients with MSH2/6-deficient EC had shorter progression-free survival than that of the low Nectin-4 expression group. The number of lymphovascular space invasion-positive patients in groups with MMR deficiency and high Nectin-4 expression was also increased compared with that in the low Nectin-4 expression group. Bioinformatics analysis revealed that alteration in Nectin-4 and MMR genes is associated with Nectin-4 expression in EC. To the best of our knowledge, this is the first study to show that Nectin-4 expression may be a potential biomarker for EC diagnosis and that high Nectin-4 expression in MMR-deficient patients with EC can predict short progression-free survival, thus providing clues to identify patients for adjuvant therapy.
    Type of Medium: Online Resource
    ISSN: 2072-6694
    URL: Article
    DOI: 10.3390/cancers15102865
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2527080-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo
    MDPI AG ; 2019
    In:  Viruses Vol. 11, No. 7 ( 2019-07-03), p. 604-
    Details
    In: Viruses, MDPI AG, Vol. 11, No. 7 ( 2019-07-03), p. 604-
    Abstract: The herbs Plantago asiatica and Clerodendrum trichotomum have been commonly used for centuries in indigenous and folk medicine in tropical and subtropical regions of the world. In this study, we show that extracts from these herbs have antiviral effects against the respiratory syncytial virus (RSV) in vitro cell cultures and an in vivo mouse model. Treatment of HEp2 cells and A549 cells with a non-cytotoxic concentration of Plantago asiatica or Clerodendrum trichotomum extract significantly reduced RSV replication, RSV-induced cell death, RSV gene transcription, RSV protein synthesis, and also blocked syncytia formation. Interestingly, oral inoculation with each herb extract significantly improved viral clearance in the lungs of BALB/c mice. Based on reported information and a high-performance liquid chromatography (HPLC) analysis, the phenolic glycoside acteoside was identified as an active chemical component of both herb extracts. An effective dose of acteoside exhibited similar antiviral effects as each herb extract against RSV in vitro and in vivo. Collectively, these results suggest that extracts of Plantago asiatica and Clerodendrum trichotomum could provide a potent natural source of an antiviral drug candidate against RSV infection.
    Type of Medium: Online Resource
    ISSN: 1999-4915
    URL: Article
    DOI: 10.3390/v11070604
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2516098-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Electrical Double Layer Mechanism Analysis of PEM Water Electrolysis for Frequency Limitation of Pulsed Currents
    MDPI AG ; 2021
    In:  Energies Vol. 14, No. 22 ( 2021-11-22), p. 7822-
    Details
    In: Energies, MDPI AG, Vol. 14, No. 22 ( 2021-11-22), p. 7822-
    Abstract: This paper proposes a method for improving hydrogen generation using pulse current in a proton exchange membrane-type electrolyzer (PEMEL). Traditional methods of electrolysis using direct current are known as the simplest approach to produce hydrogen. However, it is highly dependent on environmental variables, such as the temperature and catalyst used, to enhance the rate of electrolysis. Therefore, we propose electrolysis using a pulse current that can apply several dependent variables rather than environmental variables. The proposed method overcomes the difficulties in selecting the frequency of the pulse current by deriving factors affecting hydrogen generation while changing the concentration generated by the cell interface during the pulsed water-electrolysis process. The correlation between the electrolyzer load and the frequency characteristics was analyzed, and the limit value of the applicable frequency of the pulse current was derived through electrical modeling. In addition, the operating characteristics of PEMEL could be predicted, and the PEMEL using the proposed pulse current was verified through experiments.
    Type of Medium: Online Resource
    ISSN: 1996-1073
    URL: Article
    DOI: 10.3390/en14227822
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2437446-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Parameter Identification of Electrical Equivalent Circuits including Mass Transfer Parameters for the Selection of the Operating Frequencies of Pulsed PEM Water Electrolysis
    MDPI AG ; 2022
    In:  Energies Vol. 15, No. 24 ( 2022-12-08), p. 9303-
    Details
    In: Energies, MDPI AG, Vol. 15, No. 24 ( 2022-12-08), p. 9303-
    Abstract: This paper proposes a parameter identification method for a PEM electrolyzer electrical equivalent circuit for pulse electrolysis. Since general water electrolysis mainly uses DC currents, identifying equivalent circuit parameters using electrical characteristics mostly ignores the operation frequency and unnecessarily adheres to the secondary RC model. However, looking at the Nyquist plot of the PEM electrolyzer, it can be confirmed that identifying the operational frequency is necessary, and the secondary RC model correction is essential. Therefore, the proposed method confirms the necessity of reconstructing an electrical equivalent circuit with a primary RC model by analyzing the transient cell voltage using step current inputs and calculating an appropriate operating frequency by identifying the parameters of the reconstructed equivalent circuit. To verify the proposed parameter identification method, a simulation was constructed from the raw test data of a 400 W commercial PEM electrolyzer. In addition, the hydrogen production amount was compared to DC using a pulse electrolysis experiment at the operating frequency obtained by the proposed method.
    Type of Medium: Online Resource
    ISSN: 1996-1073
    URL: Article
    DOI: 10.3390/en15249303
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2437446-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Two-Stage Hybrid Network Clustering Using Multi-Agent Reinforcement Learning
    MDPI AG ; 2021
    In:  Electronics Vol. 10, No. 3 ( 2021-01-20), p. 232-
    Details
    In: Electronics, MDPI AG, Vol. 10, No. 3 ( 2021-01-20), p. 232-
    Abstract: In the Internet-of-Things (IoT) environments, the publish (pub)/subscribe (sub)-operated communication is widely employed. The use of pub/sub operation as a lightweight communication protocol facilitates communication among IoTs. The protocol consists of network nodes functioning as publishers, subscribers, and brokers, wherein brokers transfer messages from publishers to subscribers. Thus, the communication capability of the broker is a critical factor in the overall communication performance. In this study, multi-agent reinforcement learning (MARL) is applied to find the best combination of broker nodes. MARL goes through various combinations of broker nodes to find the best combination. However, MARL is inefficient to perform with an excessive number of broker nodes. Delaunay triangulation selects candidate broker nodes among the pool of broker nodes. The selection process operates as a preprocessing of the MARL. The suggested Delaunay triangulation is improved by the custom deletion method. Consequently, the two-stage hybrid approach outperforms any methods employing single-agent reinforcement learning (SARL). The MARL eliminates the performance fluctuation of the SARL caused by the iterative selection of broker nodes. Furthermore, the proposed approach requires a fewer number of candidate broker nodes and converges faster.
    Type of Medium: Online Resource
    ISSN: 2079-9292
    URL: Article
    DOI: 10.3390/electronics10030232
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2662127-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Adverse Effects of Classical Swine Fever Virus LOM Vaccine and Jeju LOM Strains in Pregnant Sows and Specific Pathogen-Free Pigs
    MDPI AG ; 2019
    In:  Pathogens Vol. 9, No. 1 ( 2019-12-23), p. 18-
    Details
    In: Pathogens, MDPI AG, Vol. 9, No. 1 ( 2019-12-23), p. 18-
    Abstract: In Jeju island of South Korea, a classical swine fever (CSF) non-vaccinated region, many pig farmers insisted on abortion and stillbirth in pregnant sows and high mortality of suckling/weaning piglets by circulating CSF virus from 2014 to 2018. We investigated whether CSF viruses isolated from pigs in Jeju Island (Jeju LOM) have recovered their pathogenicity by conducting experiments using pregnant sows and specific pathogen-free (SPF) pigs. The CSF modified live LOM vaccine (MLV-LOM) and Jeju LOM strains induced abortion and stillbirth in pregnant sows. Viral antigens were detected in the organs of fetuses and stillborn piglets in the absence of specific pathological lesions associated with the virulent CSF virus in both groups (MLV-LOM and Jeju LOM strain). However, antigen was detected in one newborn piglet from a sow inoculated with a Jeju LOM strain, suggesting that it may cause persistent infections in pigs. SPF pigs inoculated with the MLV-LOM or Jeju LOM strains were asymptomatic, but virus antigen was detected in several organ and blood samples. Virus shedding in both groups of animals was not detected in the feces or saliva until 21 days post inoculation. The serum concentration of the three major cytokines, IFN-α, TNF-α, and IL-10, known to be related to lymphocytopenia, were similar in both groups when the MLV-LOM or Jeju LOM strains were inoculated into SPF pigs. In conclusion, Jeju LOM strains exhibited most of the characteristics of the MLV-LOM in pigs and resulted in the same adverse effects as the MLV-LOM strain.
    Type of Medium: Online Resource
    ISSN: 2076-0817
    URL: Article
    DOI: 10.3390/pathogens9010018
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2695572-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Effect of Silane-Containing Universal Adhesives on the Bonding Strength of Lithium Disilicate
    MDPI AG ; 2021
    In:  Materials Vol. 14, No. 14 ( 2021-07-16), p. 3976-
    Details
    In: Materials, MDPI AG, Vol. 14, No. 14 ( 2021-07-16), p. 3976-
    Abstract: The purpose of this study was to investigate the effect of silane-containing universal adhesives on the bonding strength of lithium disilicate. Two-hundred-and-forty lithium disilicate blocks were divided into 16 groups according to the following surface treatments: hydrofluoric acid (HF)-treated or not, silane-treated or not, and the type of universal adhesive used (All-Bond Universal (ABU); Prime & bond (PB); Clearfil Universal Bond (CU); Single bond Universal (SBU)). After surface treatment, resin discs were bonded to each lithium disilicate using dual-cure resin cement. Bonded specimens were stored in distilled water for 24 h and then subjected to microtensile bond strength (μTBS) test. Failure modes were examined under stereomicroscope. Microscopic observation of bonded interfaces was analyzed using scanning electron microscopy. The μTBS data were statistically analyzed. Regardless of silane treatment, all groups treated with HF showed higher bonding strengths compared to those that were not treated with HF (p 〈 0.05). In groups treated with HF, the bonding strength increased after silane application (p 〈 0.05) except PB and CU (p 〉 0.05). Adhesive failures were dominant in all groups, but some mixed failures were observed in ABU treated with HF and silane. While most of the specimens that were not treated with silane after HF application only showed loose bonding between the ceramic and resin cement due to partial gaps, the specimens treated with silane application after HF showed a tight ceramic–resin interface. In conclusion, the silane in universal adhesives did not effectively improve the bonding strength between lithium disilicate and resin cement.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma14143976
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2487261-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Autonomous Landmark Calibration Method for Indoor Localization
    MDPI AG ; 2017
    In:  Sensors Vol. 17, No. 9 ( 2017-08-24), p. 1952-
    Details
    In: Sensors, MDPI AG, Vol. 17, No. 9 ( 2017-08-24), p. 1952-
    Type of Medium: Online Resource
    ISSN: 1424-8220
    URL: Article
    DOI: 10.3390/s17091952
    Language: English
    Publisher: MDPI AG
    Publication Date: 2017
    detail.hit.zdb_id: 2052857-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Comparative Analysis of Machine Learning Approaches to Predict Impact Energy of Hydraulic Breakers
    MDPI AG ; 2023
    In:  Processes Vol. 11, No. 3 ( 2023-03-05), p. 772-
    Details
    In: Processes, MDPI AG, Vol. 11, No. 3 ( 2023-03-05), p. 772-
    Abstract: Impact energy, the main performance subject of hydraulic breakers, is required to evaluate value from consumers. This study proposes a neural network algorithm-based model to predict the impact energy of a hydraulic breaker without measuring it. The proposed model was developed using 1451 data points for various parameters as an input to predict the impact energy of hydraulic breakers in a small class to a large class. Different machine learning methods have been studied, including correlation analysis, linear regression, and neural networks. The results revealed that the working pressure, working flow rate, chisel diameter, nitrogen gas pressure, operating frequency, and power significantly influenced impact energy formation. The results obtained provide a reliable model for predicting the impact energy of hydraulic circuit breakers of various sizes.
    Type of Medium: Online Resource
    ISSN: 2227-9717
    URL: Article
    DOI: 10.3390/pr11030772
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2720994-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Genetic Characterization and Phylogeographic Analysis of the First H13N6 Avian Influenza Virus Isolated from Vega Gull in South Korea
    MDPI AG ; 2024
    In:  Viruses Vol. 16, No. 2 ( 2024-02-12), p. 285-
    Details
    In: Viruses, MDPI AG, Vol. 16, No. 2 ( 2024-02-12), p. 285-
    Abstract: Avian influenza virus (AIV) is a pathogen with zoonotic and pandemic potential. Migratory birds are natural reservoirs of all known subtypes of AIVs, except for H17N10 and H18N11, and they have been implicated in previous highly pathogenic avian influenza outbreaks worldwide. This study identified and characterized the first isolate of the H13N6 subtype from a Vega gull (Larus vegae mongolicus) in South Korea. The amino acid sequence of hemagglutinin gene showed a low pathogenic AIV subtype and various amino acid substitutions were found in the sequence compared to the reference sequence and known H13 isolates. High sequence homology with other H13N6 isolates was found in HA, NA, PB1, and PA genes, but not for PB2, NP, M, and NS genes. Interestingly, various point amino acid mutations were found on all gene segments, and some are linked to an increased binding to human-type receptors, resistance to antivirals, and virulence. Evolutionary and phylogenetic analyses showed that all gene segments are gull-adapted, with a phylogeographic origin of mostly Eurasian, except for PB2, PA, and M. Findings from this study support the evidence that reassortment of AIVs continuously occurs in nature, and migratory birds are vital in the intercontinental spread of avian influenza viruses.
    Type of Medium: Online Resource
    ISSN: 1999-4915
    URL: Article
    DOI: 10.3390/v16020285
    Language: English
    Publisher: MDPI AG
    Publication Date: 2024
    detail.hit.zdb_id: 2516098-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...