In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 5 ( 2021-5-6), p. e0251333-
Abstract:
The level of serum uric acid (SUA) has been reported to be associated with left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD). However, this association remains unclear in patients with chronic kidney disease (CKD). Methods A total of 1025 patients with pre-dialysis CKD with preserved left ventricular systolic function were enrolled in this cross-sectional study. The LVH and LVDD were assessed using two-dimensional echocardiography and tissue Doppler imaging. The associations of LVH/LVDD with clinical and laboratory variables were investigated using univariable and multivariable logistic regression analyses. Results In a multivariable analysis, the SUA level was an independent predictor of LVH (odds ratio [OR]: 1.40, 95% confidence interval [CI] : 1.31–1.50, P 〈 0.001). In addition, patient age, systolic blood pressure, intact parathyroid hormone levels, and left atrial volume index levels were independent predictors of LVH. The SUA level was also an independent predictor of LVDD (OR: 1.93, 95% CI: 1.53–2.43, P 〈 0.001). Furthermore, systolic blood pressure and left atrial volume index levels were an independent predictor of LVDD. Receiver-operating characteristic curve analysis showed that the best cutoff values of SUA levels for identifying LVH and LVDD were ≥ 7.5 mg/dL and ≥ 6.3 mg/dL, respectively. Conclusion The SUA level was an independent predictor of LVD and LVDD in patients with CKD, suggesting that SUA could be a biomarker for LVH and LVDD.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0251333
DOI:
10.1371/journal.pone.0251333.g001
DOI:
10.1371/journal.pone.0251333.g002
DOI:
10.1371/journal.pone.0251333.t001
DOI:
10.1371/journal.pone.0251333.t002
DOI:
10.1371/journal.pone.0251333.t003
DOI:
10.1371/journal.pone.0251333.t004
DOI:
10.1371/journal.pone.0251333.t005
DOI:
10.1371/journal.pone.0251333.s001
DOI:
10.1371/journal.pone.0251333.s002
DOI:
10.1371/journal.pone.0251333.r001
DOI:
10.1371/journal.pone.0251333.r002
DOI:
10.1371/journal.pone.0251333.r003
DOI:
10.1371/journal.pone.0251333.r004
DOI:
10.1371/journal.pone.0251333.r005
DOI:
10.1371/journal.pone.0251333.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
Permalink