In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 8 ( 2021-8-5), p. e0255655-
Abstract:
The relationship between institutional liver transplantation (LT) case volume and clinical outcomes after liver re-transplantation is yet to be determined. Methods Patients who underwent liver re-transplantation between 2007 and 2016 were selected from the Korean National Healthcare Insurance Service database. Liver transplant centers were categorized to either high-volume centers (≥ 64 LTs/year) or low-volume centers ( 〈 64 LTs/year) according to the annual LT case volume. In-hospital and long-term mortality after liver re-transplantation were compared. Results A total of 258 liver re-transplantations were performed during the study period: 175 liver re-transplantations were performed in 3 high-volume centers and 83 were performed in 21 low-volume centers. In-hospital mortality after liver re-transplantation in high and low-volume centers were 25% and 36% ( P = 0.069), respectively. Adjusted in-hospital mortality was not different between low and high-volume centers. Adjusted 1-year mortality was significantly higher in low-volume centers (OR 2.14, 95% CI 1.05–4.37, P = 0.037) compared to high-volume centers. Long-term survival for up to 9 years was also superior in high-volume centers ( P = 0.005). Other risk factors of in-hospital mortality and 1-year mortality included female sex and higher Elixhauser comorbidity index. Conclusion Centers with higher case volume (≥ 64 LTs/year) showed lower in-hospital and overall mortality after liver re-transplantation compared to low-volume centers.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0255655
DOI:
10.1371/journal.pone.0255655.g001
DOI:
10.1371/journal.pone.0255655.g002
DOI:
10.1371/journal.pone.0255655.g003
DOI:
10.1371/journal.pone.0255655.t001
DOI:
10.1371/journal.pone.0255655.t002
DOI:
10.1371/journal.pone.0255655.t003
DOI:
10.1371/journal.pone.0255655.t004
DOI:
10.1371/journal.pone.0255655.t005
DOI:
10.1371/journal.pone.0255655.s001
DOI:
10.1371/journal.pone.0255655.r001
DOI:
10.1371/journal.pone.0255655.r002
DOI:
10.1371/journal.pone.0255655.r003
DOI:
10.1371/journal.pone.0255655.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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