In:
Nephrology Dialysis Transplantation, Oxford University Press (OUP), Vol. 38, No. Supplement_1 ( 2023-06-14)
Abstract:
Several studies have reported that dementia has a high prevalence in patients with end-stage renal disease (ESRD) patients. However, the relationship between physical activity and the risk of developing dementia has not been elucidated in ESRD patients with hemodialysis. Method A total 19,877 hemodialysis patients aged ≥ 40 years who underwent health check-ups were identified from the Korean National Health Insurance Service database and were analysed in this study. Individuals with physical activities were defined as meeting following criteria: (i) three or more days/week of vigorous activity of at least 20 min per day or (ii) five or more days/week of moderate-intensity activity of at least 30 min per day. The occurrence of dementia was monitored through the end of 2018 by the ICD-10 codes. Results During the 4.6-year follow-up, 1,755 patients with hemodialysis developed dementia. Physical activity was associated with the lower risk of any dementia (hazard ratio [HR], 0.779, 95% confidence interval (CI), 0.7-0.867) even after adjusting for several confounding factors. Risk of developing dementia was still lower in hemodialysis patients with physical activity when we analyse the risk of Alzheimer's dementia and vascular dementia separately (HR 0.817 and 0.685, respectively). In subgroup analyses, the risk of dementia tended to lower in hemodialysis patients with physical activity than without physical activity in all subgroups. Conclusion Physical activity is associated the lower risk of developing dementia in ESRD patients with hemodialysis.
Type of Medium:
Online Resource
ISSN:
0931-0509
,
1460-2385
DOI:
10.1093/ndt/gfad063c_5394
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2023
detail.hit.zdb_id:
1465709-0
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