In:
Chemistry & Biodiversity, Wiley, Vol. 20, No. 11 ( 2023-11)
Abstract:
Vitex trifolia L. is a medicinal plant and widely distributed in the northern mountainous areas of Vietnam. Phytochemical study on the fruits of this plant led to the isolation of nine iridoid derivatives ( 1 – 9 ) including three undescribed compounds ( 1 – 3 ). Their structures were elucidated to be 3′′‐hydroxyscrophuloside A 1 ( 1 ), 3′′‐hydroxycallicoside D ( 2 ), 2′‐ p‐ hydroxybenzoylaucubin ( 3 ), 6′‐ p‐ hydroxybenzoylmussaenosidic acid ( 4 ), nishindaside ( 5 ), agnuside ( 6 ), 10‐O‐vanilloylaucubin ( 7 ), 6′‐ O ‐ p‐ hydroxybenzoyl‐gardoside ( 8 ), and buddlejoside B ( 9 ) based on extensive analyses of HR‐ESI‐MS, 1D and 2D NMR spectra. Compounds 1 , 2 , 4 , and 8 significantly posessed anti‐barterial activity against Enterococcus faecalis , Staphylococcus aureus , Escherichia coli , Pseudomonas aeruginosa strains with MIC values in range of 16–64 μg/mL. At concentration of 20 μM, compounds 1 – 9 did not show cytotoxic effects against human lung cancer cells (PC9).
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.202301296
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2139001-0
SSG:
12
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