In:
Acta Pharmaceutica, Walter de Gruyter GmbH, Vol. 69, No. 3 ( 2019-09-01), p. 433-441
Abstract:
Oxidative stress is often considered detrimental for cellular processes and damaging for the lipid bi-layer. Counteracting such stresses with the aid of nature-based chemical constituents can be an ideal therapeutic approach. The current study aimed to investigate the chemical constituents of resins derived from the well-known Aloe vera and less known Commiphora mukul trees and their effect in mitigating the lipid peroxidation (LPO) process. The bio-guided isolation of bio-active fractions from both resins afforded 20 chemical constituents (17 from A. vera and 3 from C. mukul ). These compounds belonged to anthraquinones, anthraquinone glycosides, quinones, coumarins, polypodane-type terpenoids and benzene derivatives. Major chemical constituents of the resins of A. vera and C. mukul were from the classes of quinones and terpenoids. Feroxidin ( 4 , from A. vera ) showed slightly higher inhibition ( IC 50 = 201.7 ± 0.9 µmol L −1 ) than myrrhanone C ( 18 , from C. mukul : IC 50 = 210.7 ± 0.0 µmol L −1 ) and methyl 3-(4-hydroxyphenyl) propionate from A. vera ( 13 , IC 50 = 232.9 ± 0.2 µmol L −1 ) compared to the other compounds. Structure-activity relationship showed that the existence of hydroxyl, methoxy and ether groups might play a major role in countering oxidative stress. To the best of our knowledge, anti-LPO activities of compounds 1 – 4 , 14 , 18 and 20 are reported for the first time. Such chemical constituents with high anti-lipid peroxidation activity could be helpful in synthesizing candidate drugs.
Type of Medium:
Online Resource
ISSN:
1846-9558
DOI:
10.2478/acph-2019-0027
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2019
detail.hit.zdb_id:
2255569-9
SSG:
15,3
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