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  • Kayima, Joshua K.  (2)
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  • 1
    In: Journal of Transplantation, Hindawi Limited, Vol. 2015 ( 2015), p. 1-5
    Abstract: Objective. To determine the factors associated with poor blood pressure control among renal transplant recipients in a resource-limited setting. Methods . A cross-sectional study was carried out on renal transplant recipients at the Kenyatta National Hospital. Sociodemographic details, blood pressure, urine albumin : creatinine ratio, and adherence using the MMAS-8 questionnaire were noted. Independent factors associated with uncontrolled hypertension were determined using logistic regression analysis. Results . 85 subjects were evaluated. Mean age was 42.4 (SD ± 12.2) years, with a male : female ratio of 1.9 : 1. Fifty-five patients (64.7%) had uncontrolled hypertension (BP ≥ 130/80 mmHg). On univariate analysis, male sex (OR 3.7, 95% CI 1.4–9.5, p = 0.006 ), higher levels of proteinuria ( p = 0.042 ), and nonadherence to antihypertensives (OR 18, 95% CI 5.2–65.7, p 〈 0.001 ) were associated with uncontrolled hypertension. On logistic regression analysis, male sex (adjusted OR 4.6, 95% CI 1.1–19.0, p = 0.034 ) and nonadherence (adjusted OR 33.8, 95% CI 8.6–73.0, p 〈 0.001 ) were independently associated with uncontrolled hypertension. Conclusion . Factors associated with poor blood pressure control in this cohort were male sex and nonadherence to antihypertensives. Emphasis on adherence to antihypertensive therapy must be pursued within this population.
    Type of Medium: Online Resource
    ISSN: 2090-0007 , 2090-0015
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2503421-2
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  • 2
    In: International Journal of Hypertension, Hindawi Limited, Vol. 2016 ( 2016), p. 1-5
    Abstract: Objectives. To determine the changes in blood pressure levels and antihypertensive medication use in the postrenal transplantation period compared to pretransplantation one. Methods . A comparative cross-sectional study was carried out on renal transplant recipients at the Kenyatta National Hospital, a national referral hospital in Kenya. Sociodemographic details, blood pressure levels, and antihypertensive medication use before and after renal transplantation were noted. Changes in mean blood pressure levels and mean number of antihypertensive medications after renal transplantation were determined using paired t -test. Results . 85 subjects were evaluated. Mean age was 42.4 (SD ± 12.2) years, with a male : female ratio of 1.9 : 1. Compared to the pretransplant period, significantly lower mean systolic and diastolic blood pressure levels after transplantation were noted (mean SBP 144.5 mmHg versus 131.8 mmHg; mean DBP 103.6 mmHg versus 83.5 mmHg in the pre- and posttransplant periods, respectively, p 〈 0.001 ). Mean number of antihypertensive medications also reduced significantly after transplantation, with an average of 3.3 (±1.6) versus 2.1 (±0.9) in the pre- and posttransplant periods, respectively ( p 〈 0.001 ). Conclusion . There is a significant reduction in blood pressure levels and number of antihypertensive medications used after renal transplantation. The positive impact of renal transplantation on blood pressure control should be confirmed using prospective cohort studies of patients with end stage renal disease who then undergo renal transplantation.
    Type of Medium: Online Resource
    ISSN: 2090-0384 , 2090-0392
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2573167-1
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