In:
United European Gastroenterology Journal, Wiley, Vol. 1, No. 6 ( 2013-12), p. 453-460
Abstract:
Endoscopic submucosal dissection (ESD) is an optimal treatment for early gastric cancer (EGC) with negligible risk of lymph node metastasis; however, ESD is sometimes performed to treat lesions preoperatively contraindicated for the procedure due to various reasons. Here we aim to evaluate the treatment outcomes of ESD for lesions that were preoperatively contraindicated for ESD. Patients and methods Clinicopathological data of 104 EGC lesions in 104 patients were reviewed retrospectively. The demographic characteristics of patients, reasons for ESD, treatment results, complications, and outcomes were assessed. Results The major reasons for undergoing ESD included advanced age, desire to undergo ESD, and the existence of comorbidities. En‐bloc and complete resection rates were 97 and 71%, respectively. Perforation and postoperative bleeding rates were 13 and 9%, respectively. Resection was beyond the expanded Japanese criteria for endoscopic treatment of EGC in 87 patients (84%), 41 (47%) of whom underwent additional therapy, including subsequent gastrectomy (29 patients) and photodynamic therapy (12 patients). The median follow‐up period was 47 months, during which seven patients died from recurrent disease. The 5‐year overall and disease‐specific survival rates were 70 and 91.5%, respectively. Conclusions ESD is a technically demanding procedure for lesions preoperatively contraindicated for endoscopic resection. The curative resection rate was low, but the 5‐year disease‐specific survival rate of 91.5% was favourable. In experienced hands, ESD may be a treatment option for patients not suitable for radical surgery, and the relevant risk of complications must be considered before treatment.
Type of Medium:
Online Resource
ISSN:
2050-6406
,
2050-6414
DOI:
10.1177/2050640613508550
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2728585-6
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