In:
Journal of Clinical Laboratory Analysis, Wiley, Vol. 32, No. 1 ( 2018-01)
Abstract:
In this study, the pathologies of acute meningitis and encephalopathy were investigated, and biomarkers useful as prognostic indices were searched for. Methods The subjects were 31 children with meningitis, 30 with encephalopathy, and 12 with convulsions following gastroenteritis. Control group consisted of 24 children with non‐central nervous system infection. Cerebrospinal fluid cytokine analysis was performed. Results Chemokines significantly increased in the bacterial meningitis group compared with those in viral meningitis and encephalopathy groups. On comparison of interleukin( IL )‐17, it increased in cases with status epilepticus in influenza‐associated encephalopathy group. In the rotavirus encephalopathy and convulsions following gastroenteritis groups, IL ‐17 particularly increased in the convulsions following gastroenteritis group. IL ‐8 increased in all cases irrespective of the causative virus. Conclusions In the encephalopathy group, IL ‐8 may serve as a neurological prognostic index. IL ‐17 was increased in the convulsions following gastroenteritis group, particularly in cases with status epilepticus, suggesting its involvement as a convulsion‐related factor.
Type of Medium:
Online Resource
ISSN:
0887-8013
,
1098-2825
DOI:
10.1002/jcla.2018.32.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2001635-9
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