In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 10 ( 2022-10-6), p. e0275069-
Abstract:
To investigate changes in uroflowmetry parameters in men undergoing robot-assisted radical prostatectomy (RARP) for prostate cancer. Materials and methods Four hundred and twenty-eight patients received uroflowmetry testing before and after RARP from November 2011 to December 2018. Clinicopathological data, including age, initial prostate-specific antigen (PSA), prostate volume, clinical stage, body mass index (BMI), uroflowmetry parameters, and core lower urinary tract symptom scores (CLSS) were retrospectively obtained from clinical records. Changes in uroflowmetry parameters were analyzed for statistical predictors and effects on post-operative outcomes. Results A significant increase in maximum flow rate (MFR) and decreases in voided volume (VV) and post-void residual urine (PVR) were seen. In multivariate analysis, age was a negative predictor of MFR increase, while prostate volume was a positive predictor of PVR decrease and MFR increase. VV decrease led to worse incontinence symptoms, while PVR decrease and MFR increase led to improvement in voiding symptoms such as slow stream and straining. Continence recovery curves showed that VV decrease were associated with a delay in continence recovery. Conclusions Significant changes were seen in uroflowmetry results after RARP, each parameter directly related to urinary symptoms. In particular, VV decrease was associated with a worsening of incontinence symptoms and continence recovery.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0275069
DOI:
10.1371/journal.pone.0275069.g001
DOI:
10.1371/journal.pone.0275069.g002
DOI:
10.1371/journal.pone.0275069.g003
DOI:
10.1371/journal.pone.0275069.g004
DOI:
10.1371/journal.pone.0275069.t001
DOI:
10.1371/journal.pone.0275069.t002
DOI:
10.1371/journal.pone.0275069.t003
DOI:
10.1371/journal.pone.0275069.t004
DOI:
10.1371/journal.pone.0275069.s001
DOI:
10.1371/journal.pone.0275069.s002
DOI:
10.1371/journal.pone.0275069.s003
DOI:
10.1371/journal.pone.0275069.s004
DOI:
10.1371/journal.pone.0275069.s005
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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