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  • 1
    Online Resource
    Online Resource
    Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease
    Springer Science and Business Media LLC ; 2021
    In:  Scientific Reports Vol. 11, No. 1 ( 2021-09-16)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-09-16)
    Abstract: Oxidative stress is assumed to be the underlying feature of non-alcoholic fatty liver disease (NAFLD). To our knowledge, the mutual involvement of redox status homeostasis parameters [i.e., advanced oxidation protein products (AOPP), pro-oxidant-antioxidant balance (PAB), total oxidant status (TOS), total antioxidant status (TAS) and oxidative-stress index (OSI)] and cardiometabolic biomarkers in subjects with NAFLD has not been examined yet. Accordingly, we aimed to investigate t his potential relationship. A total of 122 subjects with NAFLD were compared with 56 participants without NAFLD. The diagnosis of NAFLD was confirmed by abdominal ultrasound. Anthropometric and biochemical parameters were measured. OSI, Castelli’s Risk Index I (CRI-I) and Castelli’s Risk Index II (CRI-II) were calculated. Univariate and multivariate binary logistic regression analysis were used to test the predictions of oxidative stress and cardiometabolic markers, respectively for NAFLD. Principal component analysis (PCA) was applied to explore its mutual effect on NAFLD status. Significant positive associations of CRI-I, CRI-II, high sensitivity C-reactive protein (hsCRP) and AOPP with NAFLD were found. PCA analysis extracted 3 significant factors: Oxidative stress-cardiometabolic related factor (i.e., triglycerides, AOPP, HDL-c and HbA1c)-explained 36% of variance; Pro-oxidants related factor (i.e., TOS and PAB)-explained 17% of variance; and Antioxidants related factor (i.e., TAS)-explained 15% of variance of the tested parameters. Moreover, binary logistic regression analysis revealed significant predictive ability of Oxidative stress-cardiometabolic related factor ( p   〈  0.001) and Pro-oxidants related factor ( p   〈  0.05) for NAFLD status. In addition to oxidative stress (i.e., determined by higher AOPP levels), dyslipidemia (i.e., determined by higher lipid indexes: CRI-I and CRI-II) and inflammation (determined by higher hsCRP) are independently related to NAFLD status. The mutual involvement of pro-oxidants (i.e., TOS and PAB), or the joint involvement of pro-oxidants (i.e., AOPP) and cardiometabolic parameters (i.e., HbA1c, triglycerides and HDL-c) can differentiate subjects with NAFLD from those individuals without this metabolic disorder. New studies are needed to validate our results in order to find the best therapeutic approach for NAFLD.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-021-97686-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2615211-3
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  • 2
    Online Resource
    Online Resource
    Serum soluble transferrin receptor levels are independently associated with homeostasis model assessment of insulin resistance in adolescent girls
    Termedia Sp. z.o.o. ; 2021
    In:  Archives of Medical Science
    Details
    In: Archives of Medical Science, Termedia Sp. z.o.o.
    Abstract: Markers of iron homeostasis are related to insulin resistance (IR) in adults. However, studies in children and adolescents are scarce and show contradictory results. The aim was to evaluate the potential relationship between iron status markers and IR. Additionally, no previous study has explored the mutual effect of biomarkers of iron homeostasis and inflammation (i.e. high sensitivity C-reactive protein (hsCRP)), and adipokines (i.e. retinol-binding protein 4 (RBP4)) on IR in the cohort of adolescent girls. Material and methods A total of 60 girls age between 16 and 19 years were included in the study. Serum levels of ferritin, transferrin, soluble transferrin receptor (sTfR), hsCRP, and RBP4 were measured by immunonephelometry. Homeostasis model assessment of insulin resistance (HOMA-IR) and iron homeostasis indexes were calculated. Univariate and multivariate binary logistic regression analysis were used to investigate the possible independent associations of the examined biomarkers. Principal component analysis was used to examine their mutual effect on HOMA-IR in the studied girls. Results Ferritin, sTfR, hsCRP and RBP4 were significant predictors for higher HOMA-IR in univariate analysis (p = 0.020, p = 0.009, p = 0.007, p = 0.003, respectively). Multivariate regression analysis after adjustment for waist circumference (WC) showed that serum sTfR levels remained positively associated with higher HOMA-IR (p = 0.044). Factorial analysis revealed that the obesity-inflammation related factor (i.e., WC and hsCRP) and adipokine-acute phase protein related factor (i.e., RBP4 and ferritin) showed significant differences between HOMA-IR 〈 2.5 and HOMA-IR ≥ 2.5. Conclusions Serum sTfR levels are independently associated with HOMA-IR, whereas higher serum ferritin levels together with higher RBP4 are related to higher HOMA-IR in adolescent girls.
    Type of Medium: Online Resource
    ISSN: 1734-1922 , 1896-9151
    URL: Article
    DOI: 10.5114/aoms/132757
    Language: Unknown
    Publisher: Termedia Sp. z.o.o.
    Publication Date: 2021
    detail.hit.zdb_id: 2203781-0
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  • 3
    Online Resource
    Online Resource
    The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women
    Springer Science and Business Media LLC ; 2018
    In:  Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Vol. 23, No. 1 ( 2018-2), p. 133-141
    Details
    In: Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2018-2), p. 133-141
    Type of Medium: Online Resource
    ISSN: 1124-4909 , 1590-1262
    URL: Article
    DOI: 10.1007/s40519-016-0325-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2061177-8
    SSG: 5,2
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  • 4
    Online Resource
    Online Resource
    Relationship between Cardiovascular Risk Score and Traditional and Nontraditional Cardiometabolic Parameters in Obese Adolescent Girls
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2016
    In:  Journal of Medical Biochemistry Vol. 35, No. 3 ( 2016-09-1), p. 282-292
    Details
    In: Journal of Medical Biochemistry, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 35, No. 3 ( 2016-09-1), p. 282-292
    Abstract: Background: Since the cardiovascular (CV) risk score in the young population, children and adolescents, is underestimated, especially in developing countries such as Montenegro, where a strong interaction exists between the genetically conditioned CV risk and environmental factors, the purpose of this study was to estimate CV risk in apparently healthy adolescent girls. Moreover, we aimed to test some new, emerging CV risk factors and their interaction with the traditional ones, such as obesity. Precisely, we aimed to assess the impact of low bilirubin levels, as a routine biochemical parameter, as an additional risk factor for atherosclerotic disease in the adult phase. Methods: Forty-five obese adolescent girls (mean age 17.8±1.22 years) and forty-five age-and sex-matched normal weight controls, all nonsmokers, were included. Anthropometric and biochemical parameters were measured. Cardiovascular Risk Score (CVRS) was calculated by adding the points for each risk factor (e.g. sex, HDL-c, non-HDLc, blood pressure and fasting glycemia). Results: A significant positive relationship between CVRS and ALT, hsCRP and TG/HDL-c, but an opposite relationship between CVRS and total bilirubin were found (P 〈 0.001). Multiple linear regression analysis showed that higher waist circumference (WC) and LDL-c, but lower HDL-c were independent predictors of lower bilirubin values (adjusted R 2 =0.603, P 〈 0.001). Conclusions: Obese adolescent girls are at an increased risk of cardiovascular disease late in life. In addition to the traditional risk factors, total bilirubin may have the potential to discriminate between low and higher risk for cardiovascular disturbances in healthy adolescent girls.
    Type of Medium: Online Resource
    ISSN: 1452-8266
    URL: Article
    DOI: 10.1515/jomb-2016-0005
    Language: Unknown
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2016
    detail.hit.zdb_id: 2405112-3
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  • 5
    Online Resource
    Online Resource
    Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus
    Medknow ; 2017
    In:  Journal of Research in Medical Sciences Vol. 22, No. 1 ( 2017), p. 122-
    Details
    In: Journal of Research in Medical Sciences, Medknow, Vol. 22, No. 1 ( 2017), p. 122-
    Type of Medium: Online Resource
    ISSN: 1735-1995
    URL: Article
    DOI: 10.4103/jrms.JRMS_284_17
    Language: English
    Publisher: Medknow
    Publication Date: 2017
    detail.hit.zdb_id: 2513075-4
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  • 6
    Online Resource
    Online Resource
    Retinol-binding protein 4 versus albuminuria as predictors of estimated glomerular filtration rate decline in patients with type 2 diabetes
    Medknow ; 2018
    In:  Journal of Research in Medical Sciences Vol. 23, No. 1 ( 2018), p. 44-
    Details
    In: Journal of Research in Medical Sciences, Medknow, Vol. 23, No. 1 ( 2018), p. 44-
    Type of Medium: Online Resource
    ISSN: 1735-1995
    URL: Article
    DOI: 10.4103/jrms.JRMS_893_17
    Language: English
    Publisher: Medknow
    Publication Date: 2018
    detail.hit.zdb_id: 2513075-4
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  • 7
    Online Resource
    Online Resource
    Are total bilirubin and high-sensitivity C-reactive protein independently associated with Type 2 diabetes mellitus in postmenopausal women?
    Medknow ; 2021
    In:  Journal of Research in Medical Sciences Vol. 26, No. 1 ( 2021), p. 76-
    Details
    In: Journal of Research in Medical Sciences, Medknow, Vol. 26, No. 1 ( 2021), p. 76-
    Type of Medium: Online Resource
    ISSN: 1735-1995
    URL: Article
    DOI: 10.4103/jrms.JRMS_198_18
    Language: English
    Publisher: Medknow
    Publication Date: 2021
    detail.hit.zdb_id: 2513075-4
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  • 8
    Online Resource
    Online Resource
    Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2017
    In:  Timocki medicinski glasnik Vol. 42, No. 3 ( 2017), p. 165-172
    Details
    In: Timocki medicinski glasnik, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 42, No. 3 ( 2017), p. 165-172
    Type of Medium: Online Resource
    ISSN: 0350-2899 , 2406-1042
    URL: Article
    DOI: 10.5937/tmg1703165K
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2017
    detail.hit.zdb_id: 2433190-9
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  • 9
    Online Resource
    Online Resource
    Retinol-binding protein 4 in obese and obese-diabetic postmenopausal women in Montenegro
    University of Sarajevo Faculty of Health Sciences ; 2015
    In:  Journal of Health Sciences Vol. 5, No. 3 ( 2015-12-26), p. 78-84
    Details
    In: Journal of Health Sciences, University of Sarajevo Faculty of Health Sciences, Vol. 5, No. 3 ( 2015-12-26), p. 78-84
    Abstract: Introduction: Menopause is associated with an increase in visceral fat and obesity and is the leading risk factor for insulin resistance (IR) and type 2 diabetes mellitus (T2DM). Recent evidence suggests that retinol-binding protein 4 (RBP4) is not an independent determinant of IR and its role in human glucose metabolism is not well clarified. We examined RBP4 and its association with IR, cardiometabolic and kidney parameters in obese postmenopausal women with and without T2DM.Methods: Basic anthropometric, biochemical parameters, and blood pressure (BP) were determined in 50 obese diabetic and 50 obese non-diabetic sedentary postmenopausal women, and compared with 50 healthy normal weight controls.Results: Higher levels of RBP4 were observed in obese individuals, as compared with normal weight group (p=0.033). However, we did not find significant difference between obese non-diabetic and obese-diabetic individuals (p=0.583). Serum RBP4 did not correlate with anthropometric measurements or any indicator of glucose metabolism in diabetic group, whereas RBP4 correlated with creatinine (r=0.416, p=0.003), eGFR (r= -0.304, p=0.032) and triglycerides (r=0.484, p 〈 0.001). In obese non-diabetic group, correlations were observed with fasting glucose (r=0.346, p=0.014), insulin (r=0.292, p=0.038), HOMA-IR (r=0.329 p=0.020), HbA1c (r=0.326, p=0.021), creatinine (r=0.399, p=0.004), eGFR (r= -0.389, p=0.005), HDL-c (r= -0.316, p=0.025), triglycerides (r=0.461, p 〈 0.001), and systolic BP (r=0.286, p=0.044). In multiple regression analysis, triglycerides (Beta=0.302, p 〈 0.001) and eGFR (Beta= -0.188, p=0.015) were independent predictors of RBP4.Conclusions: Serum RBP4 is not increased in obese type 2 diabetic postmenopausal women, but is associated with triglycerides and eGFR independently of diabetes.
    Type of Medium: Online Resource
    ISSN: 1986-8049 , 2232-7576
    URL: Article
    DOI: 10.17532/jhsci.2016.290
    Language: Unknown
    Publisher: University of Sarajevo Faculty of Health Sciences
    Publication Date: 2015
    detail.hit.zdb_id: 2709694-4
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  • 10
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    Online Resource
    Are visceral adiposity index and lipid accumulation product reliable indices for metabolic disturbances in patients with type 2 diabetes mellitus?
    Wiley ; 2018
    In:  Journal of Clinical Laboratory Analysis Vol. 32, No. 3 ( 2018-03)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 32, No. 3 ( 2018-03)
    Abstract: Visceral adiposity index ( VAI ) and Lipid accumulation product ( LAP ) are novel visceral adiposity indexes, proposed for the evaluation of cardiometabolic risk in adult population. Considering contradictory results obtained from many studies so far, we aimed to examine the potential benefit of applicability of VAI and LAP , over simple anthropometric indices and traditional lipid parameters in individuals with type 2 diabetes mellitus ( DM 2). Methods A total of 180 DM 2 (of them 50% females) and 119 controls who volunteered to participate in this cross‐sectional study were enrolled. Anthropometric and biochemical parameters, as well as blood pressure were obtained. VAI and LAP were calculated. Results Multivariate logistic regression analysis showed that high‐density lipoprotein cholesterol ( HDL ‐c), ( P 〈 .001), waist circumference ( WC ), ( P =.027), age ( P =.001), hypolipemic therapy ( P =.024), and LAP ( P =.005) were independent predictors of DM 2 in adjusted models. In Receiver Operating Characteristic curve analysis, used to discriminate subjects with DM 2 from those who did not have it, good accuracy of the applied procedures was only achieved with models which were consisted of parameters used in VAI (Body mass index, WC , HDL ‐c, triglycerides) and LAP ( WC , triglycerides) indexes equations, respectively [Area under the curve ( AUC )=0.819 and AUC =0.800, respectively], but not with VAI ( AUC =0.781) and LAP ( AUC =0.784) indexes themselves. Conclusion Visceral adiposity index and Lipid accumulation product may not be better than parameters that enter its equation in type 2 diabetes prediction.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.2018.32.issue-3
    DOI: 10.1002/jcla.22283
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2001635-9
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