In:
Current Nutrition & Food Science, Bentham Science Publishers Ltd., Vol. 18, No. 6 ( 2022-07), p. 549-558
Abstract:
Insulin resistance is an elemental facet of the etiology of diabetes mellitus and the principal relating factor between obesity and diabetes. Oxidative stress, lipotoxicity, inflammation and receptor dysfunction are the underlying determinants of insulin resistance commencement in metabolic illnesses. ppar-γ is a nuclear transcription factor whose activation or inhibition directly influences insulin resistance and controls glucose and lipid homeostasis by modulating gene expression. Synthetic ligands of ppar-γ are therapeutically employed to counter the hyper-glycaemia associated with obesity and type 2 diabetes, but they possess severe side effects. In the modern era, bioactive phytochemicals have been employed in the drug development process and a considerable investigation has recently been initiated to analyze the ppar-γ activating ability of diverse phytochemicals. In this review, we outlined the role of phytochemicals in insulin resistance treatment through ppar-γ activation.
Type of Medium:
Online Resource
ISSN:
1573-4013
DOI:
10.2174/1573401318666220217111415
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2022
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