In:
Macromolecular Bioscience, Wiley, Vol. 8, No. 7 ( 2008-07-07), p. 665-669
Kurzfassung:
We examined the inhibitory effect of cationic polyrotaxanes, which consist of α ‐cyclodextrins threaded on a poly(ethylene glycol) (PEG) chain, on the activity of the intestinal carnitine/organic cation transporter, OCTN2, in OCTN2 gene‐transfected HEK293/PDZK1 cells. The cationic polyrotaxanes effectively inhibited the OCTN2‐mediated carnitine transport. Polyrotaxanes with a longer PEG chain exhibited a greater inhibitory effect, possibly owing to multivalent interactions with binding sites on OCTN2. These cationic polyrotaxanes were far less cytotoxic than conventional polycations, and are therefore interesting candidates as low‐toxicity inhibitors of cation transport at cell surfaces. magnified image
Materialart:
Online-Ressource
ISSN:
1616-5187
,
1616-5195
DOI:
10.1002/mabi.200700297
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2008
ZDB Id:
2039130-4
SSG:
12
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